| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | RAD21 | Ser454 | EPSRLQEsVMEASRT | dephosphorylation down-regulates quantity by destabilization | 15737063 | SIGNOR-275536 |
| PLK1 | RAD21 | Ser175 | REIMREGsAFEDDDM | dephosphorylation down-regulates quantity by destabilization | 15737063 | SIGNOR-275535 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | dephosphorylation down-regulates ⊣ | RAD21 PSer454 | dephosphorylation up-regulates → | RAD21 | 15737063 | SIGNOR-275536 |
| PLK1 | dephosphorylation down-regulates ⊣ | RAD21 PSer175 | dephosphorylation up-regulates → | RAD21 | 15737063 | SIGNOR-275535 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | dephosphorylation![]() down-regulates quantity by destabilization | RAD21 | SIGNOR-275536 |
| PLK1 | dephosphorylation![]() down-regulates quantity by destabilization | RAD21 | SIGNOR-275535 |