| Name | NUAK1 |
| ID | O60285 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 55-306 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NUAK1 | PPP1R12A | Ser445 | LGLRKTGsYGALAEI | phosphorylation down-regulates | 20354225 | SIGNOR-164747 |
| NUAK1 | PPP1R12A | Ser472 | AGVTRSAsSPRLSSS | phosphorylation down-regulates | 20354225 | SIGNOR-164751 |
| NUAK1 | PPP1R12A | Ser910 | SLLGRSGsYSYLEER | phosphorylation down-regulates | 20354225 | SIGNOR-22572 |
| NUAK1 | LATS1 | Ser464 | NIPVRSNsFNNPLGN | phosphorylation down-regulates | 19927127 | SIGNOR-161792 |
| NUAK1 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 21317932 | SIGNOR-172008 |
| NUAK1 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 21317932 | SIGNOR-172012 |
| NUAK1 | MAPT | Ser673 | RVQSKIGsLDNITHV | phosphorylation up-regulates quantity | 27720485 | SIGNOR-279306 |
| NUAK1 | CASP6 | Ser257 | TLVNRKVsQRRVDFC | phosphorylation down-regulates activity | 15273717 | SIGNOR-250209 |
| NUAK1 | PPP1R10 | – | phosphorylation up-regulates activity | 32006464 | SIGNOR-280051 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NUAK1 | phosphorylation up-regulates → | PPP1R12A PSer445 | phosphorylation down-regulates ⊣ | PPP1R12A | 20354225 | SIGNOR-164747 |
| NUAK1 | phosphorylation up-regulates → | PPP1R12A PSer472 | phosphorylation down-regulates ⊣ | PPP1R12A | 20354225 | SIGNOR-164751 |
| NUAK1 | phosphorylation up-regulates → | PPP1R12A PSer910 | phosphorylation down-regulates ⊣ | PPP1R12A | 20354225 | SIGNOR-22572 |
| NUAK1 | phosphorylation up-regulates → | LATS1 PSer464 | phosphorylation down-regulates ⊣ | LATS1 | 19927127 | SIGNOR-161792 |
| NUAK1 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 21317932 | SIGNOR-172008 |
| NUAK1 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 21317932 | SIGNOR-172012 |
| NUAK1 | phosphorylation up-regulates → | MAPT PSer673 | phosphorylation up-regulates → | MAPT | 27720485 | SIGNOR-279306 |
| NUAK1 | phosphorylation up-regulates → | CASP6 PSer257 | phosphorylation down-regulates ⊣ | CASP6 | 15273717 | SIGNOR-250209 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NUAK1 | phosphorylation down-regulates | PPP1R12A | SIGNOR-164747 |
| NUAK1 | phosphorylation down-regulates | PPP1R12A | SIGNOR-164751 |
| NUAK1 | phosphorylation down-regulates | PPP1R12A | SIGNOR-22572 |
| NUAK1 | phosphorylation down-regulates | LATS1 | SIGNOR-161792 |
| NUAK1 | phosphorylation → up-regulates | TP53 | SIGNOR-172008 |
| NUAK1 | phosphorylation → up-regulates | TP53 | SIGNOR-172012 |
| NUAK1 | phosphorylation → up-regulates quantity | MAPT | SIGNOR-279306 |
| NUAK1 | phosphorylation → down-regulates activity | CASP6 | SIGNOR-250209 |
| NUAK1 | phosphorylation → up-regulates activity | PPP1R10 | SIGNOR-280051 |