| Name | PIP5K1C |
| ID | O60331 |
| Role | substrate |
| Enzymatic Domains |
PIPK 75-443 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | PIP5K1C | Tyr649 | TDERSWVySPLHYSA | phosphorylation up-regulates | 15738269 | SIGNOR-134459 |
| RPS6KB1 | PIP5K1C | Thr553 | QPRYRRRtQSSGQDG | phosphorylation down-regulates quantity by destabilization | 27780861 | SIGNOR-277282 |
| CDK5 | PIP5K1C | Ser650 | DERSWVYsPLHYSAQ | phosphorylation down-regulates | 15738269 | SIGNOR-134455 |
| RPS6KB1 | PIP5K1C | Ser555 | RYRRRTQsSGQDGRP | phosphorylation down-regulates quantity by destabilization | 27780861 | SIGNOR-277283 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | PIP5K1C PTyr649 | phosphorylation up-regulates → | PIP5K1C | 15738269 | SIGNOR-134459 |
| RPS6KB1 | phosphorylation up-regulates → | PIP5K1C PThr553 | phosphorylation down-regulates ⊣ | PIP5K1C | 27780861 | SIGNOR-277282 |
| CDK5 | phosphorylation up-regulates → | PIP5K1C PSer650 | phosphorylation down-regulates ⊣ | PIP5K1C | 15738269 | SIGNOR-134455 |
| RPS6KB1 | phosphorylation up-regulates → | PIP5K1C PSer555 | phosphorylation down-regulates ⊣ | PIP5K1C | 27780861 | SIGNOR-277283 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates | PIP5K1C | SIGNOR-134459 |
| RPS6KB1 | phosphorylation down-regulates quantity by destabilization | PIP5K1C | SIGNOR-277282 |
| CDK5 | phosphorylation down-regulates | PIP5K1C | SIGNOR-134455 |
| RPS6KB1 | phosphorylation down-regulates quantity by destabilization | PIP5K1C | SIGNOR-277283 |