Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PHLPP1	RAF1	Ser338	RPRGQRDsSYYWEIE	dephosphorylation down-regulates activity	24530606	SIGNOR-237449
PHLPP1	PRKCB	Ser661	QNEFAGFsYTNPEFV	dephosphorylation down-regulates quantity	18162466	SIGNOR-237047
PHLPP1	PRKCB	Ser661	QNEFAGFsYTNPEFV	dephosphorylation down-regulates quantity by destabilization	18162466	SIGNOR-248326
PHLPP1	PRKCA	Ser657	QSDFEGFsYVNPQFV	dephosphorylation down-regulates quantity	18162466	SIGNOR-237043
PHLPP1	RPS6KB1	Thr390	DSKFTRQtPVDSPDD	dephosphorylation down-regulates activity	21986499	SIGNOR-237454
PHLPP1	AKT1	Ser473	RPHFPQFsYSASGTA	dephosphorylation down-regulates	15808505	SIGNOR-252601
PHLPP1	AKT1	Ser473	RPHFPQFsYSASGTA	dephosphorylation down-regulates activity	19261608	SIGNOR-248327
PHLPP1	AKT2	–		dephosphorylation down-regulates	17386267	SIGNOR-153935
PHLPP1	AKT2	Ser474	RTHFPQFsYSASIRE	dephosphorylation down-regulates activity	19261608	SIGNOR-248328
PHLPP1	AKT2	–		dephosphorylation unknown	15808505	SIGNOR-135008
PHLPP1	STK4	Thr387	TMKRRDEtMQPAKPS	dephosphorylation up-regulates activity	20513427	SIGNOR-248329
PHLPP1	AKT3	Ser472	RPHFPQFsYSASGRE	dephosphorylation down-regulates activity	19261608	SIGNOR-248330
PHLPP1	AKT	Ser473	RPHFPQFsYSASGTA	dephosphorylation down-regulates	15808505	SIGNOR-135005
PHLPP1	AKT	–		dephosphorylation down-regulates activity	19261608	SIGNOR-248331

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PHLPP1	dephosphorylation down-regulates ⊣	RAF1 PSer338	dephosphorylation up-regulates →	RAF1	24530606	SIGNOR-237449
PHLPP1	dephosphorylation down-regulates ⊣	PRKCB PSer661	dephosphorylation up-regulates →	PRKCB	18162466	SIGNOR-237047
PHLPP1	dephosphorylation down-regulates ⊣	PRKCB PSer661	dephosphorylation up-regulates →	PRKCB	18162466	SIGNOR-248326
PHLPP1	dephosphorylation down-regulates ⊣	PRKCA PSer657	dephosphorylation up-regulates →	PRKCA	18162466	SIGNOR-237043
PHLPP1	dephosphorylation down-regulates ⊣	RPS6KB1 PThr390	dephosphorylation up-regulates →	RPS6KB1	21986499	SIGNOR-237454
PHLPP1	dephosphorylation down-regulates ⊣	AKT1 PSer473	dephosphorylation up-regulates →	AKT1	15808505	SIGNOR-252601
PHLPP1	dephosphorylation down-regulates ⊣	AKT1 PSer473	dephosphorylation up-regulates →	AKT1	19261608	SIGNOR-248327
PHLPP1	dephosphorylation down-regulates ⊣	AKT2 PSer474	dephosphorylation up-regulates →	AKT2	19261608	SIGNOR-248328
PHLPP1	dephosphorylation down-regulates ⊣	STK4 PThr387	dephosphorylation down-regulates ⊣	STK4	20513427	SIGNOR-248329
PHLPP1	dephosphorylation down-regulates ⊣	AKT3 PSer472	dephosphorylation up-regulates →	AKT3	19261608	SIGNOR-248330
PHLPP1	dephosphorylation down-regulates ⊣	AKT PSer473	dephosphorylation up-regulates →	AKT	15808505	SIGNOR-135005

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PHLPP1	dephosphorylation → down-regulates activity	RAF1	SIGNOR-237449
PHLPP1	dephosphorylation → down-regulates quantity	PRKCB	SIGNOR-237047
PHLPP1	dephosphorylation down-regulates quantity by destabilization	PRKCB	SIGNOR-248326
PHLPP1	dephosphorylation → down-regulates quantity	PRKCA	SIGNOR-237043
PHLPP1	dephosphorylation → down-regulates activity	RPS6KB1	SIGNOR-237454
PHLPP1	dephosphorylation down-regulates	AKT1	SIGNOR-252601
PHLPP1	dephosphorylation → down-regulates activity	AKT1	SIGNOR-248327
PHLPP1	dephosphorylation down-regulates	AKT2	SIGNOR-153935
PHLPP1	dephosphorylation → down-regulates activity	AKT2	SIGNOR-248328
PHLPP1	dephosphorylation → unknown	AKT2	SIGNOR-135008
PHLPP1	dephosphorylation → up-regulates activity	STK4	SIGNOR-248329
PHLPP1	dephosphorylation → down-regulates activity	AKT3	SIGNOR-248330
PHLPP1	dephosphorylation down-regulates	AKT	SIGNOR-135005
PHLPP1	dephosphorylation → down-regulates activity	AKT	SIGNOR-248331