Entity Details

Name PHLPP1
ID O60346
Role substrate
Enzymatic Domains
PH 536-636
PROSITE-ProRule
PPM-type phosphatase 1175-1422
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CSNK1A1PHLPP1Thr1363HVQSVLLtPQDEFFIphosphorylation
down-regulates quantity by destabilization		19797085SIGNOR-276262
CSNK1A1PHLPP1Ser1359VPRPHVQsVLLTPQDphosphorylation
down-regulates quantity by destabilization		19797085SIGNOR-276261
GSK3BPHLPP1Ser1359VPRPHVQsVLLTPQDphosphorylation
down-regulates quantity by destabilization		19797085SIGNOR-276263
GSK3BPHLPP1Thr1363HVQSVLLtPQDEFFIphosphorylation
down-regulates quantity by destabilization		19797085SIGNOR-276264
GSK3BPHLPP1Ser1359VPRPHVQsVLLTPQDphosphorylation
down-regulates		19797085SIGNOR-188330
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CSNK1A1phosphorylation
up-regulates
→
PHLPP1
PThr1363		phosphorylation
down-regulates
⊣		PHLPP119797085SIGNOR-276262
CSNK1A1phosphorylation
up-regulates
→
PHLPP1
PSer1359		phosphorylation
down-regulates
⊣		PHLPP119797085SIGNOR-276261
GSK3Bphosphorylation
up-regulates
→
PHLPP1
PSer1359		phosphorylation
down-regulates
⊣		PHLPP119797085SIGNOR-276263
GSK3Bphosphorylation
up-regulates
→
PHLPP1
PThr1363		phosphorylation
down-regulates
⊣		PHLPP119797085SIGNOR-276264
GSK3Bphosphorylation
up-regulates
→
PHLPP1
PSer1359		phosphorylation
down-regulates
⊣		PHLPP119797085SIGNOR-188330
Regulator Mechanism/Effect Target SIGNOR-ID
CSNK1A1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		PHLPP1SIGNOR-276262
CSNK1A1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		PHLPP1SIGNOR-276261
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		PHLPP1SIGNOR-276263
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		PHLPP1SIGNOR-276264
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates 		PHLPP1SIGNOR-188330