| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | PHLPP1 | Ser1359 | VPRPHVQsVLLTPQD | phosphorylation down-regulates quantity by destabilization | 19797085 | SIGNOR-276263 |
| GSK3B | PHLPP1 | Ser1359 | VPRPHVQsVLLTPQD | phosphorylation down-regulates | 19797085 | SIGNOR-188330 |
| CSNK1A1 | PHLPP1 | Ser1359 | VPRPHVQsVLLTPQD | phosphorylation down-regulates quantity by destabilization | 19797085 | SIGNOR-276261 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | PHLPP1 PSer1359 | phosphorylation down-regulates ⊣ | PHLPP1 | 19797085 | SIGNOR-276263 |
| GSK3B | phosphorylation up-regulates → | PHLPP1 PSer1359 | phosphorylation down-regulates ⊣ | PHLPP1 | 19797085 | SIGNOR-188330 |
| CSNK1A1 | phosphorylation up-regulates → | PHLPP1 PSer1359 | phosphorylation down-regulates ⊣ | PHLPP1 | 19797085 | SIGNOR-276261 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation![]() down-regulates quantity by destabilization | PHLPP1 | SIGNOR-276263 |
| GSK3B | phosphorylation![]() down-regulates | PHLPP1 | SIGNOR-188330 |
| CSNK1A1 | phosphorylation![]() down-regulates quantity by destabilization | PHLPP1 | SIGNOR-276261 |