| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | PHLPP1 | Thr1363 | HVQSVLLtPQDEFFI | phosphorylation down-regulates quantity by destabilization | 19797085 | SIGNOR-276264 |
| CSNK1A1 | PHLPP1 | Thr1363 | HVQSVLLtPQDEFFI | phosphorylation down-regulates quantity by destabilization | 19797085 | SIGNOR-276262 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | PHLPP1 PThr1363 | phosphorylation down-regulates ⊣ | PHLPP1 | 19797085 | SIGNOR-276264 |
| CSNK1A1 | phosphorylation up-regulates → | PHLPP1 PThr1363 | phosphorylation down-regulates ⊣ | PHLPP1 | 19797085 | SIGNOR-276262 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation![]() down-regulates quantity by destabilization | PHLPP1 | SIGNOR-276264 |
| CSNK1A1 | phosphorylation![]() down-regulates quantity by destabilization | PHLPP1 | SIGNOR-276262 |