Entity Details

Name NPHS1
ID O60500
Role substrate
Enzymatic Domains
Ig-like C2-type 1 27-130
Ig-like C2-type 2 143-234
Ig-like C2-type 3 242-333
Ig-like C2-type 4 340-434
Ig-like C2-type 5 440-540
Ig-like C2-type 6 544-635
Ig-like C2-type 7 740-832
Ig-like C2-type 8 838-939
Fibronectin type-III 943-1038
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKCANPHS1Thr1120EYEESQWtGERDTQSphosphorylation
up-regulates activity		21321125SIGNOR-178695
PRKCANPHS1Thr1125QWTGERDtQSSTVSTphosphorylation
up-regulates activity		21321125SIGNOR-172056
SRCNPHS1–phosphorylation
up-regulates activity		22718751SIGNOR-280129
FYNNPHS1–phosphorylation
up-regulates activity		12668668SIGNOR-279523
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKCAphosphorylation
up-regulates
→
NPHS1
PThr1120		phosphorylation
up-regulates
→		NPHS121321125SIGNOR-178695
PRKCAphosphorylation
up-regulates
→
NPHS1
PThr1125		phosphorylation
up-regulates
→		NPHS121321125SIGNOR-172056
Regulator Mechanism/Effect Target SIGNOR-ID
PRKCAphosphorylation
→
up-regulates activity 		NPHS1SIGNOR-178695
PRKCAphosphorylation
→
up-regulates activity 		NPHS1SIGNOR-172056
SRCphosphorylation
→
up-regulates activity 		NPHS1SIGNOR-280129
FYNphosphorylation
→
up-regulates activity 		NPHS1SIGNOR-279523