Entity Details

Name DIAPH1
ID O60610
Role substrate
Enzymatic Domains
GBD/FH3 84-449
PROSITE-ProRule
FH1 583-764
FH2 769-1171
PROSITE-ProRule
DAD 1194-1222
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ERK1/2DIAPH1Thr768PVLPFGLtPKKLYKPphosphorylation
up-regulates quantity by stabilization		23325789SIGNOR-276483
PKADIAPH1Thr768PVLPFGLtPKKLYKPphosphorylation
up-regulates quantity by stabilization		23325789SIGNOR-276484
CDK1DIAPH1–phosphorylation
down-regulates activity		30816115SIGNOR-279598
CHEK1DIAPH1–phosphorylation
down-regulates activity		28697335SIGNOR-279026
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ERK1/2phosphorylation
up-regulates
→
DIAPH1
PThr768		phosphorylation
up-regulates
→		DIAPH123325789SIGNOR-276483
PKAphosphorylation
up-regulates
→
DIAPH1
PThr768		phosphorylation
up-regulates
→		DIAPH123325789SIGNOR-276484
Regulator Mechanism/Effect Target SIGNOR-ID
ERK1/2phosphorylation
→
up-regulates quantity by stabilization 		DIAPH1SIGNOR-276483
PKAphosphorylation
→
up-regulates quantity by stabilization 		DIAPH1SIGNOR-276484
CDK1phosphorylation
→
down-regulates activity 		DIAPH1SIGNOR-279598
CHEK1phosphorylation
→
down-regulates activity 		DIAPH1SIGNOR-279026