| Name | JAK2 |
| ID | O60674 |
| Role | kinase |
| Enzymatic Domains |
FERM 37-380 PROSITE-ProRule
SH2; atypical 401-482 PROSITE-ProRule
Protein kinase 1 545-809 PROSITE-ProRule
Protein kinase 2 849-1124 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | JAK2 | Tyr972 | EYLGTKRyIHRDLAT | phosphorylation up-regulates activity | 20304997 | SIGNOR-236294 |
| JAK2 | IFNGR1 | – | phosphorylation up-regulates activity | 23898330 | SIGNOR-249490 | |
| JAK2 | EPOR | Tyr485 | GGLSDGPySNPYENS | phosphorylation up-regulates activity | 12441334 | SIGNOR-251353 |
| JAK2 | CSF2RA | – | phosphorylation up-regulates activity | 8977526 | SIGNOR-249503 | |
| JAK2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 9575217 | SIGNOR-236463 |
| JAK2 | JAK2 | Ser523 | GVSDVPTsPTLQRPT | phosphorylation down-regulates activity | 21841788 | SIGNOR-176054 |
| JAK2 | ITGB2 | – | phosphorylation up-regulates activity | 25624455 | SIGNOR-254738 | |
| JAK2 | EPOR | Tyr426 | ASAASFEyTILDPSS | phosphorylation up-regulates activity | 12441334 | SIGNOR-251349 |
| JAK2 | STAP2 | Tyr310 | LPNQEENyVTPIGDG | phosphorylation up-regulates activity | 12540842 | SIGNOR-249372 |
| JAK2 | STAM | – | phosphorylation up-regulates | 9133424 | SIGNOR-47834 | |
| JAK2 | PDP1 | Tyr94 | SILKANEySFKVPEF | phosphorylation down-regulates activity | 24962578 | SIGNOR-276642 |
| JAK2 | EPOR | Tyr454 | PTPPHLKyLYLVVSD | phosphorylation up-regulates activity | 12441334 | SIGNOR-251350 |
| JAK2 | JAK2 | Tyr813 | NSLFTPDyELLTEND | phosphorylation up-regulates activity | 15121872 | SIGNOR-235910 |
| JAK2 | BTK | – | phosphorylation up-regulates activity | 15007095 | SIGNOR-279196 | |
| JAK2 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation unknown | 9111318 | SIGNOR-251358 |
| JAK2 | CDKN1B | Tyr88 | KGSLPEFyYRPPRPP | phosphorylation down-regulates activity | 21423214 | SIGNOR-278260 |
| JAK2 | JAK2 | Tyr201 | DQTPLAIyNSISYKT | phosphorylation up-regulates activity | 17027227 | SIGNOR-251360 |
| JAK2 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation up-regulates activity | 9111318 | SIGNOR-251357 |
| JAK2 | EGFR | Tyr1069 | EDSFLQRySSDPTGA | phosphorylation up-regulates activity | 9363897 | SIGNOR-251347 |
| JAK2 | JAK2 | Tyr317 | TEQDLQLyCDFPNII | phosphorylation down-regulates | 19364823 | SIGNOR-236502 |
| JAK2 | MAP3K5 | Tyr718 | IPERDSRySQPLHEE | phosphorylation down-regulates quantity by destabilization | 19287004 | SIGNOR-276145 |
| JAK2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 9575217 | SIGNOR-238638 |
| JAK2 | EPOR | Tyr504 | AEPLPPSyVACS | phosphorylation up-regulates activity | 12441334 | SIGNOR-251355 |
| JAK2 | ITGAL | – | phosphorylation up-regulates activity | 25624455 | SIGNOR-254739 | |
| JAK2 | EPOR | Tyr368 | SEHAQDTyLVLDKWL | phosphorylation up-regulates activity | 12441334 | SIGNOR-251348 |
| JAK2 | LEPR | Tyr1141 | SKKTFASyMPQFQTC | phosphorylation up-regulates activity | 11018044 | SIGNOR-263494 |
| JAK2 | ERBB2 | – | phosphorylation up-regulates activity | 10938266 | SIGNOR-279197 | |
| JAK2 | LEPR | Tyr986 | QRQPFVKyATLISNS | phosphorylation up-regulates activity | 11018044 | SIGNOR-263493 |
| JAK2 | STAT1 | – | phosphorylation up-regulates | 21576360 | SIGNOR-256248 | |
| JAK2 | PTPN11 | Tyr327 | NSKPKKSyIATQGCL | phosphorylation up-regulates activity | 8995399 | SIGNOR-236270 |
| JAK2 | BECN1 | Tyr333 | QRYRLVPyGNHSYLE | phosphorylation up-regulates activity | 34131122 | SIGNOR-277567 |
| JAK2 | GHR | – | phosphorylation up-regulates activity | 23071812 | SIGNOR-279198 | |
| JAK2 | FGF14 | Tyr158 | Y-->S | phosphorylation up-regulates activity | 32599005 | SIGNOR-275747 |
| JAK2 | JAK2 | Tyr221 | IRAKIQDyHILTRKR | phosphorylation up-regulates activity | 15143187 | SIGNOR-251356 |
| JAK2 | CSF2RA/CSF2RB | – | phosphorylation up-regulates activity | 8977526 | SIGNOR-256001 | |
| JAK2 | BRD4 | Tyr98 | KLNLPDYyKIIKTPM | phosphorylation up-regulates quantity by stabilization | 34290255 | SIGNOR-277312 |
| JAK2 | JAK2 | Tyr966 | QICKGMEyLGTKRYI | phosphorylation up-regulates | 20304997 | SIGNOR-236290 |
| JAK2 | ESR1 | – | phosphorylation down-regulates quantity | 21907792 | SIGNOR-278949 | |
| JAK2 | EPOR | Tyr468 | DSGISTDySSGDSQG | phosphorylation up-regulates activity | 12441334 | SIGNOR-251352 |
| JAK2 | STAT4 | Tyr693 | TERGDKGyVPSVFIP | phosphorylation up-regulates | 16324152 | SIGNOR-142736 |
| JAK2 | PTPN11 | Tyr304 | PNEPVSDyINANIIM | phosphorylation up-regulates activity | 8995399 | SIGNOR-236266 |
| JAK2 | GTF2I | Tyr248 | EESEDPDyYQYNIQA | phosphorylation up-regulates activity | 11313464 | SIGNOR-235313 |
| JAK2 | STAT5A | – | phosphorylation up-regulates activity | 9575217 | SIGNOR-249507 | |
| JAK2 | ARHGEF1 | Tyr738 | WDQEAQIyELVAQTV | phosphorylation up-regulates | 20098430 | SIGNOR-163557 |
| JAK2 | KDM3A | Tyr1101 | PDLGPKMyNAYGLIT | phosphorylation up-regulates activity | 30377265 | SIGNOR-277884 |
| JAK2 | EPOR | Tyr489 | DGPYSNPyENSLIPA | phosphorylation up-regulates activity | 12441334 | SIGNOR-251354 |
| JAK2 | IFNGR2/INFGR1 | – | phosphorylation up-regulates activity | 23898330 | SIGNOR-249493 | |
| JAK2 | TET2 | Tyr1964 | HETSEPTyLRFIKSL | phosphorylation up-regulates activity | 30944118 | SIGNOR-277289 |
| JAK2 | BECN1 | Tyr333 | QRYRLVPyGNHSYLE | phosphorylation up-regulates quantity | 34131122 | SIGNOR-278312 |
| JAK2 | STAT1/STAT3 | – | phosphorylation up-regulates activity | 15526160 | SIGNOR-254999 | |
| JAK2 | CCR2 | Tyr139 | ILLTIDRyLAIVHAV | phosphorylation up-regulates activity | 9670957 | SIGNOR-251345 |
| JAK2 | JAK2 | Tyr570 | VRREVGDyGQLHETE | phosphorylation down-regulates activity | 15143187 | SIGNOR-251359 |
| JAK2 | STAT1 | – | phosphorylation up-regulates | 7888666 | SIGNOR-255071 | |
| JAK2 | STAT6 | – | phosphorylation up-regulates activity | 18852293 | SIGNOR-249532 | |
| JAK2 | JAK2 | Tyr570 | VRREVGDyGQLHETE | phosphorylation down-regulates activity | 21841788 | SIGNOR-176058 |
| JAK2 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates | 9575217 | SIGNOR-56827 |
| JAK2 | CTLA4 | Tyr201 | SPLTTGVyVKMPPTE | phosphorylation up-regulates quantity by stabilization | 10842319 | SIGNOR-251346 |
| JAK2 | ATOH1 | Tyr80 | CTARAAQyLLHSPEL | phosphorylation up-regulates quantity | 29168692 | SIGNOR-262201 |
| JAK2 | MAP3K5 | Tyr718 | IPERDSRySQPLHEE | phosphorylation down-regulates | 19287004 | SIGNOR-184600 |
| JAK2 | CSF2RA/CSF2RB | – | phosphorylation up-regulates activity | 19436055 | SIGNOR-255584 | |
| JAK2 | EZH2 | Tyr641 | KNEFISEyCGEIISQ | phosphorylation down-regulates | 24469040 | SIGNOR-202711 |
| JAK2 | RAF1 | Tyr341 | GQRDSSYyWEIEASE | phosphorylation up-regulates activity | 8876196 | SIGNOR-251362 |
| JAK2 | PRMT5 | Tyr297 | NRPPPNAyELFAKGY | phosphorylation down-regulates | 21316606 | SIGNOR-171994 |
| JAK2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates | 15322115 | SIGNOR-235709 |
| JAK2 | GAB2 | Tyr643 | TSDEKVDyVQVDKEK | phosphorylation up-regulates | 18644434 | SIGNOR-179488 |
| JAK2 | EPOR | Tyr456 | PPHLKYLyLVVSDSG | phosphorylation up-regulates activity | 12441334 | SIGNOR-251351 |
| JAK2 | STAP2 | Tyr250 | PFLLDEDyEKVLGYV | phosphorylation up-regulates activity | 12540842 | SIGNOR-249371 |
| JAK2 | BRD4 | Tyr97 | VKLNLPDyYKIIKTP | phosphorylation up-regulates quantity by stabilization | 34290255 | SIGNOR-277313 |
| JAK2 | JAK2 | Tyr637 | KFGSLDTyLKKNKNC | phosphorylation up-regulates activity | 19364823 | SIGNOR-235885 |
| JAK2 | JAK2 | Tyr221 | IRAKIQDyHILTRKR | phosphorylation up-regulates | 15143187 | SIGNOR-236506 |
| JAK2 | RAF1 | Tyr340 | RGQRDSSyYWEIEAS | phosphorylation up-regulates activity | 8876196 | SIGNOR-251361 |
| JAK2 | STAT6 | – | phosphorylation up-regulates activity | 9852261 | SIGNOR-62585 | |
| JAK2 | STAT5B | – | phosphorylation up-regulates | 9575217 | SIGNOR-56894 | |
| JAK2 | TET2 | Tyr1939 | CEKYGPDyVPQKSHG | phosphorylation up-regulates activity | 30944118 | SIGNOR-277290 |
| JAK2 | JAK2 | Tyr868 | GSVEMCRyDPLQDNT | phosphorylation up-regulates | 20304997 | SIGNOR-236298 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr972 | phosphorylation up-regulates → | JAK2 | 20304997 | SIGNOR-236294 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr485 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251353 |
| JAK2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 9575217 | SIGNOR-236463 |
| JAK2 | phosphorylation up-regulates → | JAK2 PSer523 | phosphorylation down-regulates ⊣ | JAK2 | 21841788 | SIGNOR-176054 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr426 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251349 |
| JAK2 | phosphorylation up-regulates → | STAP2 PTyr310 | phosphorylation up-regulates → | STAP2 | 12540842 | SIGNOR-249372 |
| JAK2 | phosphorylation up-regulates → | PDP1 PTyr94 | phosphorylation down-regulates ⊣ | PDP1 | 24962578 | SIGNOR-276642 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr454 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251350 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr813 | phosphorylation up-regulates → | JAK2 | 15121872 | SIGNOR-235910 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation down-regulates ⊣ | JAK2 | 9111318 | SIGNOR-251358 |
| JAK2 | phosphorylation up-regulates → | CDKN1B PTyr88 | phosphorylation down-regulates ⊣ | CDKN1B | 21423214 | SIGNOR-278260 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr201 | phosphorylation up-regulates → | JAK2 | 17027227 | SIGNOR-251360 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation up-regulates → | JAK2 | 9111318 | SIGNOR-251357 |
| JAK2 | phosphorylation up-regulates → | EGFR PTyr1069 | phosphorylation up-regulates → | EGFR | 9363897 | SIGNOR-251347 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr317 | phosphorylation down-regulates ⊣ | JAK2 | 19364823 | SIGNOR-236502 |
| JAK2 | phosphorylation up-regulates → | MAP3K5 PTyr718 | phosphorylation down-regulates ⊣ | MAP3K5 | 19287004 | SIGNOR-276145 |
| JAK2 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 9575217 | SIGNOR-238638 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr504 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251355 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr368 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251348 |
| JAK2 | phosphorylation up-regulates → | LEPR PTyr1141 | phosphorylation up-regulates → | LEPR | 11018044 | SIGNOR-263494 |
| JAK2 | phosphorylation up-regulates → | LEPR PTyr986 | phosphorylation up-regulates → | LEPR | 11018044 | SIGNOR-263493 |
| JAK2 | phosphorylation up-regulates → | PTPN11 PTyr327 | phosphorylation up-regulates → | PTPN11 | 8995399 | SIGNOR-236270 |
| JAK2 | phosphorylation up-regulates → | BECN1 PTyr333 | phosphorylation up-regulates → | BECN1 | 34131122 | SIGNOR-277567 |
| JAK2 | phosphorylation up-regulates → | FGF14 PTyr158 | phosphorylation up-regulates → | FGF14 | 32599005 | SIGNOR-275747 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr221 | phosphorylation up-regulates → | JAK2 | 15143187 | SIGNOR-251356 |
| JAK2 | phosphorylation up-regulates → | BRD4 PTyr98 | phosphorylation up-regulates → | BRD4 | 34290255 | SIGNOR-277312 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr966 | phosphorylation up-regulates → | JAK2 | 20304997 | SIGNOR-236290 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr468 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251352 |
| JAK2 | phosphorylation up-regulates → | STAT4 PTyr693 | phosphorylation up-regulates → | STAT4 | 16324152 | SIGNOR-142736 |
| JAK2 | phosphorylation up-regulates → | PTPN11 PTyr304 | phosphorylation up-regulates → | PTPN11 | 8995399 | SIGNOR-236266 |
| JAK2 | phosphorylation up-regulates → | GTF2I PTyr248 | phosphorylation up-regulates → | GTF2I | 11313464 | SIGNOR-235313 |
| JAK2 | phosphorylation up-regulates → | ARHGEF1 PTyr738 | phosphorylation up-regulates → | ARHGEF1 | 20098430 | SIGNOR-163557 |
| JAK2 | phosphorylation up-regulates → | KDM3A PTyr1101 | phosphorylation up-regulates → | KDM3A | 30377265 | SIGNOR-277884 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr489 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251354 |
| JAK2 | phosphorylation up-regulates → | TET2 PTyr1964 | phosphorylation up-regulates → | TET2 | 30944118 | SIGNOR-277289 |
| JAK2 | phosphorylation up-regulates → | BECN1 PTyr333 | phosphorylation up-regulates → | BECN1 | 34131122 | SIGNOR-278312 |
| JAK2 | phosphorylation up-regulates → | CCR2 PTyr139 | phosphorylation up-regulates → | CCR2 | 9670957 | SIGNOR-251345 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr570 | phosphorylation down-regulates ⊣ | JAK2 | 15143187 | SIGNOR-251359 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr570 | phosphorylation down-regulates ⊣ | JAK2 | 21841788 | SIGNOR-176058 |
| JAK2 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 9575217 | SIGNOR-56827 |
| JAK2 | phosphorylation up-regulates → | CTLA4 PTyr201 | phosphorylation up-regulates → | CTLA4 | 10842319 | SIGNOR-251346 |
| JAK2 | phosphorylation up-regulates → | ATOH1 PTyr80 | phosphorylation up-regulates → | ATOH1 | 29168692 | SIGNOR-262201 |
| JAK2 | phosphorylation up-regulates → | MAP3K5 PTyr718 | phosphorylation down-regulates ⊣ | MAP3K5 | 19287004 | SIGNOR-184600 |
| JAK2 | phosphorylation up-regulates → | EZH2 PTyr641 | phosphorylation down-regulates ⊣ | EZH2 | 24469040 | SIGNOR-202711 |
| JAK2 | phosphorylation up-regulates → | RAF1 PTyr341 | phosphorylation up-regulates → | RAF1 | 8876196 | SIGNOR-251362 |
| JAK2 | phosphorylation up-regulates → | PRMT5 PTyr297 | phosphorylation down-regulates ⊣ | PRMT5 | 21316606 | SIGNOR-171994 |
| JAK2 | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 15322115 | SIGNOR-235709 |
| JAK2 | phosphorylation up-regulates → | GAB2 PTyr643 | phosphorylation up-regulates → | GAB2 | 18644434 | SIGNOR-179488 |
| JAK2 | phosphorylation up-regulates → | EPOR PTyr456 | phosphorylation up-regulates → | EPOR | 12441334 | SIGNOR-251351 |
| JAK2 | phosphorylation up-regulates → | STAP2 PTyr250 | phosphorylation up-regulates → | STAP2 | 12540842 | SIGNOR-249371 |
| JAK2 | phosphorylation up-regulates → | BRD4 PTyr97 | phosphorylation up-regulates → | BRD4 | 34290255 | SIGNOR-277313 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr637 | phosphorylation up-regulates → | JAK2 | 19364823 | SIGNOR-235885 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr221 | phosphorylation up-regulates → | JAK2 | 15143187 | SIGNOR-236506 |
| JAK2 | phosphorylation up-regulates → | RAF1 PTyr340 | phosphorylation up-regulates → | RAF1 | 8876196 | SIGNOR-251361 |
| JAK2 | phosphorylation up-regulates → | TET2 PTyr1939 | phosphorylation up-regulates → | TET2 | 30944118 | SIGNOR-277290 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr868 | phosphorylation up-regulates → | JAK2 | 20304997 | SIGNOR-236298 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-236294 |
| JAK2 | phosphorylation → up-regulates activity | IFNGR1 | SIGNOR-249490 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251353 |
| JAK2 | phosphorylation → up-regulates activity | CSF2RA | SIGNOR-249503 |
| JAK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-236463 |
| JAK2 | phosphorylation → down-regulates activity | JAK2 | SIGNOR-176054 |
| JAK2 | phosphorylation → up-regulates activity | ITGB2 | SIGNOR-254738 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251349 |
| JAK2 | phosphorylation → up-regulates activity | STAP2 | SIGNOR-249372 |
| JAK2 | phosphorylation → up-regulates | STAM | SIGNOR-47834 |
| JAK2 | phosphorylation → down-regulates activity | PDP1 | SIGNOR-276642 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251350 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-235910 |
| JAK2 | phosphorylation → up-regulates activity | BTK | SIGNOR-279196 |
| JAK2 | phosphorylation → unknown | JAK2 | SIGNOR-251358 |
| JAK2 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-278260 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-251360 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-251357 |
| JAK2 | phosphorylation → up-regulates activity | EGFR | SIGNOR-251347 |
| JAK2 | phosphorylation down-regulates | JAK2 | SIGNOR-236502 |
| JAK2 | phosphorylation down-regulates quantity by destabilization | MAP3K5 | SIGNOR-276145 |
| JAK2 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-238638 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251355 |
| JAK2 | phosphorylation → up-regulates activity | ITGAL | SIGNOR-254739 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251348 |
| JAK2 | phosphorylation → up-regulates activity | LEPR | SIGNOR-263494 |
| JAK2 | phosphorylation → up-regulates activity | ERBB2 | SIGNOR-279197 |
| JAK2 | phosphorylation → up-regulates activity | LEPR | SIGNOR-263493 |
| JAK2 | phosphorylation → up-regulates | STAT1 | SIGNOR-256248 |
| JAK2 | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-236270 |
| JAK2 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-277567 |
| JAK2 | phosphorylation → up-regulates activity | GHR | SIGNOR-279198 |
| JAK2 | phosphorylation → up-regulates activity | FGF14 | SIGNOR-275747 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-251356 |
| JAK2 | phosphorylation → up-regulates activity | CSF2RA/CSF2RB | SIGNOR-256001 |
| JAK2 | phosphorylation → up-regulates quantity by stabilization | BRD4 | SIGNOR-277312 |
| JAK2 | phosphorylation → up-regulates | JAK2 | SIGNOR-236290 |
| JAK2 | phosphorylation → down-regulates quantity | ESR1 | SIGNOR-278949 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251352 |
| JAK2 | phosphorylation → up-regulates | STAT4 | SIGNOR-142736 |
| JAK2 | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-236266 |
| JAK2 | phosphorylation → up-regulates activity | GTF2I | SIGNOR-235313 |
| JAK2 | phosphorylation → up-regulates activity | STAT5A | SIGNOR-249507 |
| JAK2 | phosphorylation → up-regulates | ARHGEF1 | SIGNOR-163557 |
| JAK2 | phosphorylation → up-regulates activity | KDM3A | SIGNOR-277884 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251354 |
| JAK2 | phosphorylation → up-regulates activity | IFNGR2/INFGR1 | SIGNOR-249493 |
| JAK2 | phosphorylation → up-regulates activity | TET2 | SIGNOR-277289 |
| JAK2 | phosphorylation → up-regulates quantity | BECN1 | SIGNOR-278312 |
| JAK2 | phosphorylation → up-regulates activity | STAT1/STAT3 | SIGNOR-254999 |
| JAK2 | phosphorylation → up-regulates activity | CCR2 | SIGNOR-251345 |
| JAK2 | phosphorylation → down-regulates activity | JAK2 | SIGNOR-251359 |
| JAK2 | phosphorylation → up-regulates | STAT1 | SIGNOR-255071 |
| JAK2 | phosphorylation → up-regulates activity | STAT6 | SIGNOR-249532 |
| JAK2 | phosphorylation → down-regulates activity | JAK2 | SIGNOR-176058 |
| JAK2 | phosphorylation → up-regulates | STAT5A | SIGNOR-56827 |
| JAK2 | phosphorylation → up-regulates quantity by stabilization | CTLA4 | SIGNOR-251346 |
| JAK2 | phosphorylation → up-regulates quantity | ATOH1 | SIGNOR-262201 |
| JAK2 | phosphorylation down-regulates | MAP3K5 | SIGNOR-184600 |
| JAK2 | phosphorylation → up-regulates activity | CSF2RA/CSF2RB | SIGNOR-255584 |
| JAK2 | phosphorylation down-regulates | EZH2 | SIGNOR-202711 |
| JAK2 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-251362 |
| JAK2 | phosphorylation down-regulates | PRMT5 | SIGNOR-171994 |
| JAK2 | phosphorylation → up-regulates | STAT1 | SIGNOR-235709 |
| JAK2 | phosphorylation → up-regulates | GAB2 | SIGNOR-179488 |
| JAK2 | phosphorylation → up-regulates activity | EPOR | SIGNOR-251351 |
| JAK2 | phosphorylation → up-regulates activity | STAP2 | SIGNOR-249371 |
| JAK2 | phosphorylation → up-regulates quantity by stabilization | BRD4 | SIGNOR-277313 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-235885 |
| JAK2 | phosphorylation → up-regulates | JAK2 | SIGNOR-236506 |
| JAK2 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-251361 |
| JAK2 | phosphorylation → up-regulates activity | STAT6 | SIGNOR-62585 |
| JAK2 | phosphorylation → up-regulates | STAT5B | SIGNOR-56894 |
| JAK2 | phosphorylation → up-regulates activity | TET2 | SIGNOR-277290 |
| JAK2 | phosphorylation → up-regulates | JAK2 | SIGNOR-236298 |