| Name | JAK2 |
| ID | O60674 |
| Role | substrate |
| Enzymatic Domains |
FERM 37-380 PROSITE-ProRule
SH2; atypical 401-482 PROSITE-ProRule
Protein kinase 1 545-809 PROSITE-ProRule
Protein kinase 2 849-1124 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | JAK2 | Ser523 | GVSDVPTsPTLQRPT | phosphorylation down-regulates activity | 21841788 | SIGNOR-176054 |
| PTPN1 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates activity | 11970898 | SIGNOR-248404 |
| JAK2 | JAK2 | Tyr813 | NSLFTPDyELLTEND | phosphorylation up-regulates activity | 15121872 | SIGNOR-235910 |
| JAK2 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation unknown | 9111318 | SIGNOR-251358 |
| MAPK3 | JAK2 | Ser523 | GVSDVPTsPTLQRPT | phosphorylation down-regulates | 16705159 | SIGNOR-146747 |
| JAK2 | JAK2 | Tyr201 | DQTPLAIyNSISYKT | phosphorylation up-regulates activity | 17027227 | SIGNOR-251360 |
| JAK2 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation up-regulates activity | 9111318 | SIGNOR-251357 |
| JAK2 | JAK2 | Tyr317 | TEQDLQLyCDFPNII | phosphorylation down-regulates | 19364823 | SIGNOR-236502 |
| PTPN1 | JAK2 | Tyr1008 | LPQDKEYyKVKEPGE | dephosphorylation down-regulates | 15780598 | SIGNOR-133852 |
| PTPN11 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation up-regulates quantity by stabilization | 14522994 | SIGNOR-248665 |
| PRKCA | JAK2 | Ser518 | VFRTNGVsDVPTSPT | phosphorylation up-regulates activity | 27368100 | SIGNOR-277261 |
| PTPN12 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates activity | 11731619 | SIGNOR-248657 |
| Gbeta | JAK2 | – | phosphorylation down-regulates | 16705159 | SIGNOR-270046 | |
| EPHA4 | JAK2 | – | phosphorylation up-regulates activity | 28686668 | SIGNOR-279040 | |
| JAK2 | JAK2 | Tyr221 | IRAKIQDyHILTRKR | phosphorylation up-regulates activity | 15143187 | SIGNOR-251356 |
| PTPRC | JAK2 | Tyr1008 | LPQDKEYyKVKEPGE | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248349 |
| PTPRJ | JAK2 | Tyr813 | NSLFTPDyELLTEND | dephosphorylation down-regulates activity | 28912580 | SIGNOR-277093 |
| PTPRC | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248348 |
| MAPK1 | JAK2 | Ser523 | GVSDVPTsPTLQRPT | phosphorylation down-regulates | 16705159 | SIGNOR-236331 |
| JAK2 | JAK2 | Tyr966 | QICKGMEyLGTKRYI | phosphorylation up-regulates | 20304997 | SIGNOR-236290 |
| IL6ST | JAK2 | Tyr1008 | LPQDKEYyKVKEPGE | phosphorylation up-regulates activity | 9716487 | SIGNOR-238634 |
| PTPRC | JAK2 | – | dephosphorylation down-regulates activity | 24252238 | SIGNOR-255679 | |
| PTPN12 | JAK2 | Tyr1008 | LPQDKEYyKVKEPGE | dephosphorylation down-regulates activity | 11731619 | SIGNOR-248658 |
| PTPN11 | JAK2 | Tyr570 | VRREVGDyGQLHETE | dephosphorylation up-regulates activity | 30108215 | SIGNOR-277037 |
| PTPN12 | JAK2 | – | dephosphorylation down-regulates | 11731619 | SIGNOR-112383 | |
| JAK2 | JAK2 | Tyr570 | VRREVGDyGQLHETE | phosphorylation down-regulates activity | 15143187 | SIGNOR-251359 |
| PTPN1 | JAK2 | – | dephosphorylation down-regulates | 15821101 | SIGNOR-135207 | |
| JAK2 | JAK2 | Tyr570 | VRREVGDyGQLHETE | phosphorylation down-regulates activity | 21841788 | SIGNOR-176058 |
| PTPRG | JAK2 | Tyr1008 | LPQDKEYyKVKEPGE | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254690 |
| PTPRC | JAK2 | – | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248347 | |
| PTPN6 | JAK2 | – | dephosphorylation down-regulates activity | 8943354 | SIGNOR-248466 | |
| PTPRG | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254689 |
| PTPN1 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates | 15821101 | SIGNOR-134955 |
| IL10RA | JAK2 | – | phosphorylation up-regulates activity | 26260587 | SIGNOR-249545 | |
| IL4R | JAK2 | – | phosphorylation up-regulates activity | 18852293 | SIGNOR-249530 | |
| IL6ST | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation up-regulates activity | 9716487 | SIGNOR-238630 |
| IL5RA | JAK2 | – | phosphorylation up-regulates activity | 7602114 | SIGNOR-254352 | |
| JAK2 | JAK2 | Tyr637 | KFGSLDTyLKKNKNC | phosphorylation up-regulates activity | 19364823 | SIGNOR-235885 |
| ABL1 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation up-regulates activity | 11593427 | SIGNOR-245365 |
| IL6R | JAK2 | – | phosphorylation up-regulates activity | 23869758 | SIGNOR-254405 | |
| ERK1/2 | JAK2 | Ser523 | GVSDVPTsPTLQRPT | phosphorylation down-regulates | 16705159 | SIGNOR-244553 |
| JAK2 | JAK2 | Tyr221 | IRAKIQDyHILTRKR | phosphorylation up-regulates | 15143187 | SIGNOR-236506 |
| JAK2 | JAK2 | Tyr868 | GSVEMCRyDPLQDNT | phosphorylation up-regulates | 20304997 | SIGNOR-236298 |
| JAK2 | JAK2 | Tyr972 | EYLGTKRyIHRDLAT | phosphorylation up-regulates activity | 20304997 | SIGNOR-236294 |
| PTPRJ | JAK2 | Tyr868 | GSVEMCRyDPLQDNT | dephosphorylation down-regulates activity | 28912580 | SIGNOR-277094 |
| PTPN1 | JAK2 | Tyr1008 | LPQDKEYyKVKEPGE | dephosphorylation down-regulates activity | 11970898 | SIGNOR-248405 |
| PRKCA | JAK2 | Thr174 | KVPVTHEtQEECLGM | phosphorylation up-regulates activity | 27368100 | SIGNOR-277262 |
| BCR-ABL | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation up-regulates activity | 11593427 | SIGNOR-255812 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | phosphorylation up-regulates → | JAK2 PSer523 | phosphorylation down-regulates ⊣ | JAK2 | 21841788 | SIGNOR-176054 |
| PTPN1 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 11970898 | SIGNOR-248404 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr813 | phosphorylation up-regulates → | JAK2 | 15121872 | SIGNOR-235910 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation down-regulates ⊣ | JAK2 | 9111318 | SIGNOR-251358 |
| MAPK3 | phosphorylation up-regulates → | JAK2 PSer523 | phosphorylation down-regulates ⊣ | JAK2 | 16705159 | SIGNOR-146747 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr201 | phosphorylation up-regulates → | JAK2 | 17027227 | SIGNOR-251360 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation up-regulates → | JAK2 | 9111318 | SIGNOR-251357 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr317 | phosphorylation down-regulates ⊣ | JAK2 | 19364823 | SIGNOR-236502 |
| PTPN1 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1008 | dephosphorylation up-regulates → | JAK2 | 15780598 | SIGNOR-133852 |
| PTPN11 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation down-regulates ⊣ | JAK2 | 14522994 | SIGNOR-248665 |
| PRKCA | phosphorylation up-regulates → | JAK2 PSer518 | phosphorylation up-regulates → | JAK2 | 27368100 | SIGNOR-277261 |
| PTPN12 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 11731619 | SIGNOR-248657 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr221 | phosphorylation up-regulates → | JAK2 | 15143187 | SIGNOR-251356 |
| PTPRC | dephosphorylation down-regulates ⊣ | JAK2 PTyr1008 | dephosphorylation up-regulates → | JAK2 | 11201744 | SIGNOR-248349 |
| PTPRJ | dephosphorylation down-regulates ⊣ | JAK2 PTyr813 | dephosphorylation up-regulates → | JAK2 | 28912580 | SIGNOR-277093 |
| PTPRC | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 11201744 | SIGNOR-248348 |
| MAPK1 | phosphorylation up-regulates → | JAK2 PSer523 | phosphorylation down-regulates ⊣ | JAK2 | 16705159 | SIGNOR-236331 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr966 | phosphorylation up-regulates → | JAK2 | 20304997 | SIGNOR-236290 |
| IL6ST | phosphorylation up-regulates → | JAK2 PTyr1008 | phosphorylation up-regulates → | JAK2 | 9716487 | SIGNOR-238634 |
| PTPN12 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1008 | dephosphorylation up-regulates → | JAK2 | 11731619 | SIGNOR-248658 |
| PTPN11 | dephosphorylation down-regulates ⊣ | JAK2 PTyr570 | dephosphorylation down-regulates ⊣ | JAK2 | 30108215 | SIGNOR-277037 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr570 | phosphorylation down-regulates ⊣ | JAK2 | 15143187 | SIGNOR-251359 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr570 | phosphorylation down-regulates ⊣ | JAK2 | 21841788 | SIGNOR-176058 |
| PTPRG | dephosphorylation down-regulates ⊣ | JAK2 PTyr1008 | dephosphorylation up-regulates → | JAK2 | 25624455 | SIGNOR-254690 |
| PTPRG | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 25624455 | SIGNOR-254689 |
| PTPN1 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 15821101 | SIGNOR-134955 |
| IL6ST | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation up-regulates → | JAK2 | 9716487 | SIGNOR-238630 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr637 | phosphorylation up-regulates → | JAK2 | 19364823 | SIGNOR-235885 |
| ABL1 | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation up-regulates → | JAK2 | 11593427 | SIGNOR-245365 |
| ERK1/2 | phosphorylation up-regulates → | JAK2 PSer523 | phosphorylation down-regulates ⊣ | JAK2 | 16705159 | SIGNOR-244553 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr221 | phosphorylation up-regulates → | JAK2 | 15143187 | SIGNOR-236506 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr868 | phosphorylation up-regulates → | JAK2 | 20304997 | SIGNOR-236298 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr972 | phosphorylation up-regulates → | JAK2 | 20304997 | SIGNOR-236294 |
| PTPRJ | dephosphorylation down-regulates ⊣ | JAK2 PTyr868 | dephosphorylation up-regulates → | JAK2 | 28912580 | SIGNOR-277094 |
| PTPN1 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1008 | dephosphorylation up-regulates → | JAK2 | 11970898 | SIGNOR-248405 |
| PRKCA | phosphorylation up-regulates → | JAK2 PThr174 | phosphorylation up-regulates → | JAK2 | 27368100 | SIGNOR-277262 |
| BCR-ABL | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation up-regulates → | JAK2 | 11593427 | SIGNOR-255812 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK2 | phosphorylation → down-regulates activity | JAK2 | SIGNOR-176054 |
| PTPN1 | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248404 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-235910 |
| JAK2 | phosphorylation → unknown | JAK2 | SIGNOR-251358 |
| MAPK3 | phosphorylation down-regulates | JAK2 | SIGNOR-146747 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-251360 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-251357 |
| JAK2 | phosphorylation down-regulates | JAK2 | SIGNOR-236502 |
| PTPN1 | dephosphorylation down-regulates | JAK2 | SIGNOR-133852 |
| PTPN11 | dephosphorylation → up-regulates quantity by stabilization | JAK2 | SIGNOR-248665 |
| PRKCA | phosphorylation → up-regulates activity | JAK2 | SIGNOR-277261 |
| PTPN12 | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248657 |
| Gbeta | phosphorylation down-regulates | JAK2 | SIGNOR-270046 |
| EPHA4 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-279040 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-251356 |
| PTPRC | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248349 |
| PTPRJ | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-277093 |
| PTPRC | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248348 |
| MAPK1 | phosphorylation down-regulates | JAK2 | SIGNOR-236331 |
| JAK2 | phosphorylation → up-regulates | JAK2 | SIGNOR-236290 |
| IL6ST | phosphorylation → up-regulates activity | JAK2 | SIGNOR-238634 |
| PTPRC | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-255679 |
| PTPN12 | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248658 |
| PTPN11 | dephosphorylation → up-regulates activity | JAK2 | SIGNOR-277037 |
| PTPN12 | dephosphorylation down-regulates | JAK2 | SIGNOR-112383 |
| JAK2 | phosphorylation → down-regulates activity | JAK2 | SIGNOR-251359 |
| PTPN1 | dephosphorylation down-regulates | JAK2 | SIGNOR-135207 |
| JAK2 | phosphorylation → down-regulates activity | JAK2 | SIGNOR-176058 |
| PTPRG | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-254690 |
| PTPRC | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248347 |
| PTPN6 | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248466 |
| PTPRG | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-254689 |
| PTPN1 | dephosphorylation down-regulates | JAK2 | SIGNOR-134955 |
| IL10RA | phosphorylation → up-regulates activity | JAK2 | SIGNOR-249545 |
| IL4R | phosphorylation → up-regulates activity | JAK2 | SIGNOR-249530 |
| IL6ST | phosphorylation → up-regulates activity | JAK2 | SIGNOR-238630 |
| IL5RA | phosphorylation → up-regulates activity | JAK2 | SIGNOR-254352 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-235885 |
| ABL1 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-245365 |
| IL6R | phosphorylation → up-regulates activity | JAK2 | SIGNOR-254405 |
| ERK1/2 | phosphorylation down-regulates | JAK2 | SIGNOR-244553 |
| JAK2 | phosphorylation → up-regulates | JAK2 | SIGNOR-236506 |
| JAK2 | phosphorylation → up-regulates | JAK2 | SIGNOR-236298 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-236294 |
| PTPRJ | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-277094 |
| PTPN1 | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248405 |
| PRKCA | phosphorylation → up-regulates activity | JAK2 | SIGNOR-277262 |
| BCR-ABL | phosphorylation → up-regulates activity | JAK2 | SIGNOR-255812 |