| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254689 |
| PTPN1 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates | 15821101 | SIGNOR-134955 |
| IL6ST | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation up-regulates activity | 9716487 | SIGNOR-238630 |
| ABL1 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation up-regulates activity | 11593427 | SIGNOR-245365 |
| BCR-ABL | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation up-regulates activity | 11593427 | SIGNOR-255812 |
| PTPN1 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates activity | 11970898 | SIGNOR-248404 |
| JAK2 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation unknown | 9111318 | SIGNOR-251358 |
| JAK2 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | phosphorylation up-regulates activity | 9111318 | SIGNOR-251357 |
| PTPN11 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation up-regulates quantity by stabilization | 14522994 | SIGNOR-248665 |
| PTPN12 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates activity | 11731619 | SIGNOR-248657 |
| PTPRC | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248348 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 25624455 | SIGNOR-254689 |
| PTPN1 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 15821101 | SIGNOR-134955 |
| IL6ST | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation up-regulates → | JAK2 | 9716487 | SIGNOR-238630 |
| ABL1 | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation up-regulates → | JAK2 | 11593427 | SIGNOR-245365 |
| BCR-ABL | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation up-regulates → | JAK2 | 11593427 | SIGNOR-255812 |
| PTPN1 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 11970898 | SIGNOR-248404 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation down-regulates ⊣ | JAK2 | 9111318 | SIGNOR-251358 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr1007 | phosphorylation up-regulates → | JAK2 | 9111318 | SIGNOR-251357 |
| PTPN11 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation down-regulates ⊣ | JAK2 | 14522994 | SIGNOR-248665 |
| PTPN12 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 11731619 | SIGNOR-248657 |
| PTPRC | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 11201744 | SIGNOR-248348 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRG | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-254689 |
| PTPN1 | dephosphorylation down-regulates | JAK2 | SIGNOR-134955 |
| IL6ST | phosphorylation → up-regulates activity | JAK2 | SIGNOR-238630 |
| ABL1 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-245365 |
| BCR-ABL | phosphorylation → up-regulates activity | JAK2 | SIGNOR-255812 |
| PTPN1 | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248404 |
| JAK2 | phosphorylation → unknown | JAK2 | SIGNOR-251358 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-251357 |
| PTPN11 | dephosphorylation → up-regulates quantity by stabilization | JAK2 | SIGNOR-248665 |
| PTPN12 | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248657 |
| PTPRC | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248348 |
