Entity Details

Name JAK2_Tyr1008
ID O60674
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPN1JAK2Tyr1008LPQDKEYyKVKEPGEdephosphorylation
down-regulates		15780598SIGNOR-133852
PTPRCJAK2Tyr1008LPQDKEYyKVKEPGEdephosphorylation
down-regulates activity		11201744SIGNOR-248349
IL6STJAK2Tyr1008LPQDKEYyKVKEPGEphosphorylation
up-regulates activity		9716487SIGNOR-238634
PTPN12JAK2Tyr1008LPQDKEYyKVKEPGEdephosphorylation
down-regulates activity		11731619SIGNOR-248658
PTPRGJAK2Tyr1008LPQDKEYyKVKEPGEdephosphorylation
down-regulates activity		25624455SIGNOR-254690
PTPN1JAK2Tyr1008LPQDKEYyKVKEPGEdephosphorylation
down-regulates activity		11970898SIGNOR-248405
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPN1dephosphorylation
down-regulates
⊣
JAK2
PTyr1008		dephosphorylation
up-regulates
→		JAK215780598SIGNOR-133852
PTPRCdephosphorylation
down-regulates
⊣
JAK2
PTyr1008		dephosphorylation
up-regulates
→		JAK211201744SIGNOR-248349
IL6STphosphorylation
up-regulates
→
JAK2
PTyr1008		phosphorylation
up-regulates
→		JAK29716487SIGNOR-238634
PTPN12dephosphorylation
down-regulates
⊣
JAK2
PTyr1008		dephosphorylation
up-regulates
→		JAK211731619SIGNOR-248658
PTPRGdephosphorylation
down-regulates
⊣
JAK2
PTyr1008		dephosphorylation
up-regulates
→		JAK225624455SIGNOR-254690
PTPN1dephosphorylation
down-regulates
⊣
JAK2
PTyr1008		dephosphorylation
up-regulates
→		JAK211970898SIGNOR-248405
Regulator Mechanism/Effect Target SIGNOR-ID
PTPN1dephosphorylation
img/direct_inhibition.png
down-regulates 		JAK2SIGNOR-133852
PTPRCdephosphorylation
→
down-regulates activity 		JAK2SIGNOR-248349
IL6STphosphorylation
→
up-regulates activity 		JAK2SIGNOR-238634
PTPN12dephosphorylation
→
down-regulates activity 		JAK2SIGNOR-248658
PTPRGdephosphorylation
→
down-regulates activity 		JAK2SIGNOR-254690
PTPN1dephosphorylation
→
down-regulates activity 		JAK2SIGNOR-248405