| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | JAK2 | Tyr221 | IRAKIQDyHILTRKR | phosphorylation up-regulates | 15143187 | SIGNOR-236506 |
| JAK2 | JAK2 | Tyr221 | IRAKIQDyHILTRKR | phosphorylation up-regulates activity | 15143187 | SIGNOR-251356 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr221 | phosphorylation up-regulates → | JAK2 | 15143187 | SIGNOR-236506 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr221 | phosphorylation up-regulates → | JAK2 | 15143187 | SIGNOR-251356 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK2 | phosphorylation → up-regulates | JAK2 | SIGNOR-236506 |
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-251356 |
