Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PTPN11	JAK2	Tyr570 View in OncoXplorer	VRREVGDyGQLHETE	dephosphorylation up-regulates activity	30108215	SIGNOR-277037
JAK2	JAK2	Tyr570 View in OncoXplorer	VRREVGDyGQLHETE	phosphorylation down-regulates activity	15143187	SIGNOR-251359
JAK2	JAK2	Tyr570 View in OncoXplorer	VRREVGDyGQLHETE	phosphorylation down-regulates activity	21841788	SIGNOR-176058

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PTPN11	dephosphorylation down-regulates ⊣	JAK2 PTyr570	dephosphorylation down-regulates ⊣	JAK2	30108215	SIGNOR-277037
JAK2	phosphorylation up-regulates →	JAK2 PTyr570	phosphorylation down-regulates ⊣	JAK2	15143187	SIGNOR-251359
JAK2	phosphorylation up-regulates →	JAK2 PTyr570	phosphorylation down-regulates ⊣	JAK2	21841788	SIGNOR-176058

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PTPN11	dephosphorylation → up-regulates activity	JAK2	SIGNOR-277037
JAK2	phosphorylation → down-regulates activity	JAK2	SIGNOR-251359
JAK2	phosphorylation → down-regulates activity	JAK2	SIGNOR-176058