| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | JAK2 | Tyr868 | GSVEMCRyDPLQDNT | dephosphorylation down-regulates activity | 28912580 | SIGNOR-277094 |
| JAK2 | JAK2 | Tyr868 | GSVEMCRyDPLQDNT | phosphorylation up-regulates | 20304997 | SIGNOR-236298 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | dephosphorylation down-regulates ⊣ | JAK2 PTyr868 | dephosphorylation up-regulates → | JAK2 | 28912580 | SIGNOR-277094 |
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr868 | phosphorylation up-regulates → | JAK2 | 20304997 | SIGNOR-236298 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRJ | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-277094 |
| JAK2 | phosphorylation → up-regulates | JAK2 | SIGNOR-236298 |
