| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | JAK2 | Ser523 | GVSDVPTsPTLQRPT | phosphorylation down-regulates | 16705159 | SIGNOR-244553 |
| JAK2 | JAK2 | Ser523 | GVSDVPTsPTLQRPT | phosphorylation down-regulates activity | 21841788 | SIGNOR-176054 |
| MAPK3 | JAK2 | Ser523 | GVSDVPTsPTLQRPT | phosphorylation down-regulates | 16705159 | SIGNOR-146747 |
| MAPK1 | JAK2 | Ser523 | GVSDVPTsPTLQRPT | phosphorylation down-regulates | 16705159 | SIGNOR-236331 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | JAK2 PSer523 | phosphorylation down-regulates ⊣ | JAK2 | 16705159 | SIGNOR-244553 |
| JAK2 | phosphorylation up-regulates → | JAK2 PSer523 | phosphorylation down-regulates ⊣ | JAK2 | 21841788 | SIGNOR-176054 |
| MAPK3 | phosphorylation up-regulates → | JAK2 PSer523 | phosphorylation down-regulates ⊣ | JAK2 | 16705159 | SIGNOR-146747 |
| MAPK1 | phosphorylation up-regulates → | JAK2 PSer523 | phosphorylation down-regulates ⊣ | JAK2 | 16705159 | SIGNOR-236331 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation down-regulates | JAK2 | SIGNOR-244553 |
| JAK2 | phosphorylation → down-regulates activity | JAK2 | SIGNOR-176054 |
| MAPK3 | phosphorylation down-regulates | JAK2 | SIGNOR-146747 |
| MAPK1 | phosphorylation down-regulates | JAK2 | SIGNOR-236331 |
