| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | JAK2 | Tyr813 | NSLFTPDyELLTEND | phosphorylation up-regulates activity | 15121872 | SIGNOR-235910 |
| PTPRJ | JAK2 | Tyr813 | NSLFTPDyELLTEND | dephosphorylation down-regulates activity | 28912580 | SIGNOR-277093 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | phosphorylation up-regulates → | JAK2 PTyr813 | phosphorylation up-regulates → | JAK2 | 15121872 | SIGNOR-235910 |
| PTPRJ | dephosphorylation down-regulates ⊣ | JAK2 PTyr813 | dephosphorylation up-regulates → | JAK2 | 28912580 | SIGNOR-277093 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK2 | phosphorylation → up-regulates activity | JAK2 | SIGNOR-235910 |
| PTPRJ | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-277093 |
