| Name | CDC14B |
| ID | O60729 |
| Role | phosphatase |
| Enzymatic Domains |
Tyrosine-protein phosphatase 214-374 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC14B | TP53 | Ser315 | LPNNTSSsPQPKKKP | dephosphorylation down-regulates activity | 10644693 | SIGNOR-248332 |
| CDC14B | CDH1 | – | dephosphorylation up-regulates activity | 18662541 | SIGNOR-277017 | |
| CDC14B | APC | – | dephosphorylation up-regulates | 18662541 | SIGNOR-179636 | |
| CDC14B | SKP2 | Ser64 | SNLGHPEsPPRKRLK | dephosphorylation down-regulates quantity by destabilization | 18239684 | SIGNOR-248333 |
| CDC14B | TAF1C | – | dephosphorylation up-regulates activity | 26023773 | SIGNOR-277135 | |
| CDC14B | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | dephosphorylation down-regulates | 20236090 | SIGNOR-164471 |
| CDC14B | MAPK6 | Ser688 | QFHSPVGsPLKSIQA | dephosphorylation down-regulates | 20236090 | SIGNOR-164475 |
| CDC14B | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | dephosphorylation down-regulates | 20236090 | SIGNOR-164479 |
| CDC14B | MAPK6 | Thr698 | KSIQATLtPSAMKSS | dephosphorylation down-regulates | 20236090 | SIGNOR-164483 |
| CDC14B | MAPK6 | Ser684 | IGIPQFHsPVGSPLK | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248334 |
| CDC14B | MAPK6 | Ser688 | QFHSPVGsPLKSIQA | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248335 |
| CDC14B | MAPK6 | Ser705 | TPSAMKSsPQIPHQT | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248337 |
| CDC14B | MAPK6 | Thr698 | KSIQATLtPSAMKSS | dephosphorylation down-regulates quantity by destabilization | 20236090 | SIGNOR-248336 |
| CDC14B | SIRT2 | Ser368 | PNPSTSAsPKKSPPP | dephosphorylation unknown | 17488717 | SIGNOR-248338 |
| CDC14B | USP9X | Ser2547 | YEGSEEVsPPQTKDQ | dephosphorylation down-regulates quantity by destabilization | 32152317 | SIGNOR-275613 |
| CDC14B | CDCA3 | – | dephosphorylation up-regulates | 18662541 | SIGNOR-179664 | |
| CDC14B | KMT5A | Ser100 | SKIYSYMsPNKCSGM | dephosphorylation down-regulates quantity by destabilization | 20966048 | SIGNOR-248339 |
| CDC14B | GSK3B/Axin/APC | – | dephosphorylation up-regulates | 18662541 | SIGNOR-227927 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC14B | dephosphorylation down-regulates ⊣ | TP53 PSer315 | dephosphorylation up-regulates → | TP53 | 10644693 | SIGNOR-248332 |
| CDC14B | dephosphorylation down-regulates ⊣ | SKP2 PSer64 | dephosphorylation up-regulates → | SKP2 | 18239684 | SIGNOR-248333 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer684 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164471 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer688 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164475 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer705 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164479 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PThr698 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-164483 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer684 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248334 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer688 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248335 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PSer705 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248337 |
| CDC14B | dephosphorylation down-regulates ⊣ | MAPK6 PThr698 | dephosphorylation up-regulates → | MAPK6 | 20236090 | SIGNOR-248336 |
| CDC14B | dephosphorylation down-regulates ⊣ | SIRT2 PSer368 | dephosphorylation up-regulates → | SIRT2 | 17488717 | SIGNOR-248338 |
| CDC14B | dephosphorylation down-regulates ⊣ | USP9X PSer2547 | dephosphorylation up-regulates → | USP9X | 32152317 | SIGNOR-275613 |
| CDC14B | dephosphorylation down-regulates ⊣ | KMT5A PSer100 | dephosphorylation up-regulates → | KMT5A | 20966048 | SIGNOR-248339 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC14B | dephosphorylation → down-regulates activity | TP53 | SIGNOR-248332 |
| CDC14B | dephosphorylation → up-regulates activity | CDH1 | SIGNOR-277017 |
| CDC14B | dephosphorylation → up-regulates | APC | SIGNOR-179636 |
| CDC14B | dephosphorylation down-regulates quantity by destabilization | SKP2 | SIGNOR-248333 |
| CDC14B | dephosphorylation → up-regulates activity | TAF1C | SIGNOR-277135 |
| CDC14B | dephosphorylation down-regulates | MAPK6 | SIGNOR-164471 |
| CDC14B | dephosphorylation down-regulates | MAPK6 | SIGNOR-164475 |
| CDC14B | dephosphorylation down-regulates | MAPK6 | SIGNOR-164479 |
| CDC14B | dephosphorylation down-regulates | MAPK6 | SIGNOR-164483 |
| CDC14B | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248334 |
| CDC14B | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248335 |
| CDC14B | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248337 |
| CDC14B | dephosphorylation down-regulates quantity by destabilization | MAPK6 | SIGNOR-248336 |
| CDC14B | dephosphorylation → unknown | SIRT2 | SIGNOR-248338 |
| CDC14B | dephosphorylation down-regulates quantity by destabilization | USP9X | SIGNOR-275613 |
| CDC14B | dephosphorylation → up-regulates | CDCA3 | SIGNOR-179664 |
| CDC14B | dephosphorylation down-regulates quantity by destabilization | KMT5A | SIGNOR-248339 |
| CDC14B | dephosphorylation → up-regulates | GSK3B/Axin/APC | SIGNOR-227927 |