| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation up-regulates activity | 23457334 | SIGNOR-192260 |
| PRKCA | PFKFB2 | Thr475 | TPLSSSNtIRRPRNY | phosphorylation up-regulates activity | 1322130 | SIGNOR-248844 |
| PRKAA1 | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 11069105 | SIGNOR-84061 |
| AMPK | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 20640476 | SIGNOR-209947 |
| AKT1 | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation up-regulates activity | 12853467 | SIGNOR-252464 |
| AKT1 | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 12853467 | SIGNOR-252555 |
| AKT | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation unknown | 12853467 | SIGNOR-251485 |
| AMPK | PFKFB2 | Ser466 | PVRMRRNsFTPLSSSN | phosphorylation up-regulates activity | 11069105 | SIGNOR-260011 |
| PRKACA | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 12853467 | SIGNOR-250025 |
| RPS6KA3 | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 9211863 | SIGNOR-49367 |
| AKT | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation up-regulates activity | 12853467 | SIGNOR-103462 |
| AKT1 | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation unknown | 12853467 | SIGNOR-252575 |
| AKT | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 12853467 | SIGNOR-248031 |
| AKT1 | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation unknown | 12853467 | SIGNOR-252574 |
| AKT1 | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 10521487 | SIGNOR-252584 |
| RPS6KB1 | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 9211863 | SIGNOR-49371 |
| AKT1 | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation up-regulates activity | 23457334 | SIGNOR-252528 |
| AKT | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 10521487 | SIGNOR-71419 |
| PRKAA2 | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 11069105 | SIGNOR-250323 |
| PRKAA1 | PFKFB2 | Ser466 | PVRMRRNsFTPLSSSN | phosphorylation up-regulates activity | 11069105 | SIGNOR-260012 |
| AMPK | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 11069105 | SIGNOR-216623 |
| RPS6KA3 | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 2846551 | SIGNOR-23753 |
| AKT | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation unknown | 12853467 | SIGNOR-251484 |
| RPS6KB1 | PFKFB2 | Ser466 | PVRMRRNsFTPLSSS | phosphorylation up-regulates activity | 2846551 | SIGNOR-23757 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation up-regulates → | PFKFB2 | 23457334 | SIGNOR-192260 |
| PRKCA | phosphorylation up-regulates → | PFKFB2 PThr475 | phosphorylation up-regulates → | PFKFB2 | 1322130 | SIGNOR-248844 |
| PRKAA1 | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 11069105 | SIGNOR-84061 |
| AMPK | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 20640476 | SIGNOR-209947 |
| AKT1 | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation up-regulates → | PFKFB2 | 12853467 | SIGNOR-252464 |
| AKT1 | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 12853467 | SIGNOR-252555 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation down-regulates ⊣ | PFKFB2 | 12853467 | SIGNOR-251485 |
| AMPK | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 11069105 | SIGNOR-260011 |
| PRKACA | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 12853467 | SIGNOR-250025 |
| RPS6KA3 | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 9211863 | SIGNOR-49367 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation up-regulates → | PFKFB2 | 12853467 | SIGNOR-103462 |
| AKT1 | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation down-regulates ⊣ | PFKFB2 | 12853467 | SIGNOR-252575 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 12853467 | SIGNOR-248031 |
| AKT1 | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation down-regulates ⊣ | PFKFB2 | 12853467 | SIGNOR-252574 |
| AKT1 | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 10521487 | SIGNOR-252584 |
| RPS6KB1 | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 9211863 | SIGNOR-49371 |
| AKT1 | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation up-regulates → | PFKFB2 | 23457334 | SIGNOR-252528 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 10521487 | SIGNOR-71419 |
| PRKAA2 | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 11069105 | SIGNOR-250323 |
| PRKAA1 | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 11069105 | SIGNOR-260012 |
| AMPK | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 11069105 | SIGNOR-216623 |
| RPS6KA3 | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 2846551 | SIGNOR-23753 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation down-regulates ⊣ | PFKFB2 | 12853467 | SIGNOR-251484 |
| RPS6KB1 | phosphorylation up-regulates → | PFKFB2 PSer466 | phosphorylation up-regulates → | PFKFB2 | 2846551 | SIGNOR-23757 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-192260 |
| PRKCA | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-248844 |
| PRKAA1 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-84061 |
| AMPK | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-209947 |
| AKT1 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-252464 |
| AKT1 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-252555 |
| AKT | phosphorylation → unknown | PFKFB2 | SIGNOR-251485 |
| AMPK | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-260011 |
| PRKACA | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-250025 |
| RPS6KA3 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-49367 |
| AKT | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-103462 |
| AKT1 | phosphorylation → unknown | PFKFB2 | SIGNOR-252575 |
| AKT | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-248031 |
| AKT1 | phosphorylation → unknown | PFKFB2 | SIGNOR-252574 |
| AKT1 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-252584 |
| RPS6KB1 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-49371 |
| AKT1 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-252528 |
| AKT | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-71419 |
| PRKAA2 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-250323 |
| PRKAA1 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-260012 |
| AMPK | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-216623 |
| RPS6KA3 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-23753 |
| AKT | phosphorylation → unknown | PFKFB2 | SIGNOR-251484 |
| RPS6KB1 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-23757 |
