| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation up-regulates activity | 12853467 | SIGNOR-252464 |
| AKT | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation up-regulates activity | 23457334 | SIGNOR-192260 |
| AKT | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation unknown | 12853467 | SIGNOR-251485 |
| AKT1 | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation unknown | 12853467 | SIGNOR-252575 |
| AKT1 | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation up-regulates activity | 23457334 | SIGNOR-252528 |
| AKT | PFKFB2 | Ser483 | IRRPRNYsVGSRPLK | phosphorylation up-regulates activity | 12853467 | SIGNOR-103462 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation up-regulates → | PFKFB2 | 12853467 | SIGNOR-252464 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation up-regulates → | PFKFB2 | 23457334 | SIGNOR-192260 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation down-regulates ⊣ | PFKFB2 | 12853467 | SIGNOR-251485 |
| AKT1 | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation down-regulates ⊣ | PFKFB2 | 12853467 | SIGNOR-252575 |
| AKT1 | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation up-regulates → | PFKFB2 | 23457334 | SIGNOR-252528 |
| AKT | phosphorylation up-regulates → | PFKFB2 PSer483 | phosphorylation up-regulates → | PFKFB2 | 12853467 | SIGNOR-103462 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-252464 |
| AKT | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-192260 |
| AKT | phosphorylation → unknown | PFKFB2 | SIGNOR-251485 |
| AKT1 | phosphorylation → unknown | PFKFB2 | SIGNOR-252575 |
| AKT1 | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-252528 |
| AKT | phosphorylation → up-regulates activity | PFKFB2 | SIGNOR-103462 |
