Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AKT	PFKFB2	Ser483 View in OncoXplorer	IRRPRNYsVGSRPLK	phosphorylation unknown	12853467	SIGNOR-251485
AKT1	PFKFB2	Ser483 View in OncoXplorer	IRRPRNYsVGSRPLK	phosphorylation unknown	12853467	SIGNOR-252575
AKT1	PFKFB2	Ser483 View in OncoXplorer	IRRPRNYsVGSRPLK	phosphorylation up-regulates activity	23457334	SIGNOR-252528
AKT	PFKFB2	Ser483 View in OncoXplorer	IRRPRNYsVGSRPLK	phosphorylation up-regulates activity	12853467	SIGNOR-103462
AKT1	PFKFB2	Ser483 View in OncoXplorer	IRRPRNYsVGSRPLK	phosphorylation up-regulates activity	12853467	SIGNOR-252464
AKT	PFKFB2	Ser483 View in OncoXplorer	IRRPRNYsVGSRPLK	phosphorylation up-regulates activity	23457334	SIGNOR-192260

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AKT	phosphorylation up-regulates →	PFKFB2 PSer483	phosphorylation down-regulates ⊣	PFKFB2	12853467	SIGNOR-251485
AKT1	phosphorylation up-regulates →	PFKFB2 PSer483	phosphorylation down-regulates ⊣	PFKFB2	12853467	SIGNOR-252575
AKT1	phosphorylation up-regulates →	PFKFB2 PSer483	phosphorylation up-regulates →	PFKFB2	23457334	SIGNOR-252528
AKT	phosphorylation up-regulates →	PFKFB2 PSer483	phosphorylation up-regulates →	PFKFB2	12853467	SIGNOR-103462
AKT1	phosphorylation up-regulates →	PFKFB2 PSer483	phosphorylation up-regulates →	PFKFB2	12853467	SIGNOR-252464
AKT	phosphorylation up-regulates →	PFKFB2 PSer483	phosphorylation up-regulates →	PFKFB2	23457334	SIGNOR-192260

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AKT	phosphorylation → unknown	PFKFB2	SIGNOR-251485
AKT1	phosphorylation → unknown	PFKFB2	SIGNOR-252575
AKT1	phosphorylation → up-regulates activity	PFKFB2	SIGNOR-252528
AKT	phosphorylation → up-regulates activity	PFKFB2	SIGNOR-103462
AKT1	phosphorylation → up-regulates activity	PFKFB2	SIGNOR-252464
AKT	phosphorylation → up-regulates activity	PFKFB2	SIGNOR-192260