| Name | BRD4 |
| ID | O60885 |
| Role | kinase |
| Enzymatic Domains |
Bromo 1 58-164 PROSITE-ProRule
Bromo 2 348-457 PROSITE-ProRule
NET 600-682 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BRD4 | MYC | Thr58 | KKFELLPtPPLSPSR | phosphorylation down-regulates quantity by destabilization | 32482868 | SIGNOR-262046 |
| BRD4 | POLR2A | Ser1616 | TPQSPSYsPTSPSYS | phosphorylation up-regulates | 22509028 | SIGNOR-197012 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BRD4 | phosphorylation up-regulates → | MYC PThr58 | phosphorylation down-regulates ⊣ | MYC | 32482868 | SIGNOR-262046 |
| BRD4 | phosphorylation up-regulates → | POLR2A PSer1616 | phosphorylation up-regulates → | POLR2A | 22509028 | SIGNOR-197012 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BRD4 | phosphorylation down-regulates quantity by destabilization | MYC | SIGNOR-262046 |
| BRD4 | phosphorylation → up-regulates | POLR2A | SIGNOR-197012 |