| Name | MITF |
| ID | O75030 |
| Role | substrate |
| Enzymatic Domains |
bHLH 311-364 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | MITF | – | phosphorylation down-regulates quantity by destabilization | 33875769 | SIGNOR-279050 | |
| CLK4 | MITF | Tyr360 | ILKASVDyIRKLQRE | phosphorylation down-regulates quantity by destabilization | 35092699 | SIGNOR-274116 |
| RPS6KA1 | MITF | Ser409 | HGLSLIPsTGLCSPD | phosphorylation down-regulates | 10673502 | SIGNOR-75034 |
| ERK1/2 | MITF | Ser180 | PGSSAPNsPMAMLTL | phosphorylation down-regulates | 10673502 | SIGNOR-249575 |
| RPS6K | MITF | Ser409 | HGLSLIPsTGLCSPD | phosphorylation down-regulates | 21749389 | SIGNOR-252795 |
| MAPK1 | MITF | Ser180 | PGSSAPNsPMAMLTL | phosphorylation down-regulates | 10673502 | SIGNOR-75030 |
| MAPK3 | MITF | Ser180 | PGSSAPNsPMAMLTL | phosphorylation down-regulates quantity by destabilization | 10841026 | SIGNOR-249620 |
| RPS6K | MITF | Ser409 | HGLSLIPsTGLCSPD | phosphorylation down-regulates | 10673502 | SIGNOR-252791 |
| RPS6KA1 | MITF | Ser409 | HGLSLIPsTGLCSPD | phosphorylation down-regulates | 21749389 | SIGNOR-174760 |
| GSK3B | MITF | Ser405 | QARAHGLsLIPSTGL | phosphorylation up-regulates activity | 10587587 | SIGNOR-275967 |
| GSK3B | MITF | Ser405 | QARAHGLsLIPSTGL | phosphorylation up-regulates quantity by stabilization | 25605940 | SIGNOR-276475 |
| GSK3B | MITF | Ser405 | QARAHGLsLIPSTGL | phosphorylation up-regulates quantity by stabilization | 25605940 | SIGNOR-276477 |
| PRKDC | MITF | Ser431 | S-->C | phosphorylation up-regulates activity | 38316520 | SIGNOR-277899 |
| GSK3A | MITF | Ser405 | QARAHGLsLIPSTGL | phosphorylation up-regulates | 10587587 | SIGNOR-72878 |
| Gbeta | MITF | – | phosphorylation down-regulates quantity by destabilization | 10841026 | SIGNOR-270029 | |
| GSK3B | MITF | Ser419 | S-->N | phosphorylation up-regulates quantity by stabilization | 25605940 | SIGNOR-276476 |
| GSK3B | MITF | – | phosphorylation up-regulates activity | 21873430 | SIGNOR-276356 | |
| AKT1 | MITF | Ser516 | KTSSRRSsMSMEETE | phosphorylation down-regulates quantity by destabilization | 27702651 | SIGNOR-277281 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CLK4 | phosphorylation up-regulates → | MITF PTyr360 | phosphorylation down-regulates ⊣ | MITF | 35092699 | SIGNOR-274116 |
| RPS6KA1 | phosphorylation up-regulates → | MITF PSer409 | phosphorylation down-regulates ⊣ | MITF | 10673502 | SIGNOR-75034 |
| ERK1/2 | phosphorylation up-regulates → | MITF PSer180 | phosphorylation down-regulates ⊣ | MITF | 10673502 | SIGNOR-249575 |
| RPS6K | phosphorylation up-regulates → | MITF PSer409 | phosphorylation down-regulates ⊣ | MITF | 21749389 | SIGNOR-252795 |
| MAPK1 | phosphorylation up-regulates → | MITF PSer180 | phosphorylation down-regulates ⊣ | MITF | 10673502 | SIGNOR-75030 |
| MAPK3 | phosphorylation up-regulates → | MITF PSer180 | phosphorylation down-regulates ⊣ | MITF | 10841026 | SIGNOR-249620 |
| RPS6K | phosphorylation up-regulates → | MITF PSer409 | phosphorylation down-regulates ⊣ | MITF | 10673502 | SIGNOR-252791 |
| RPS6KA1 | phosphorylation up-regulates → | MITF PSer409 | phosphorylation down-regulates ⊣ | MITF | 21749389 | SIGNOR-174760 |
| GSK3B | phosphorylation up-regulates → | MITF PSer405 | phosphorylation up-regulates → | MITF | 10587587 | SIGNOR-275967 |
| GSK3B | phosphorylation up-regulates → | MITF PSer405 | phosphorylation up-regulates → | MITF | 25605940 | SIGNOR-276475 |
| GSK3B | phosphorylation up-regulates → | MITF PSer405 | phosphorylation up-regulates → | MITF | 25605940 | SIGNOR-276477 |
| PRKDC | phosphorylation up-regulates → | MITF PSer431 | phosphorylation up-regulates → | MITF | 38316520 | SIGNOR-277899 |
| GSK3A | phosphorylation up-regulates → | MITF PSer405 | phosphorylation up-regulates → | MITF | 10587587 | SIGNOR-72878 |
| GSK3B | phosphorylation up-regulates → | MITF PSer419 | phosphorylation up-regulates → | MITF | 25605940 | SIGNOR-276476 |
| AKT1 | phosphorylation up-regulates → | MITF PSer516 | phosphorylation down-regulates ⊣ | MITF | 27702651 | SIGNOR-277281 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates quantity by destabilization | MITF | SIGNOR-279050 |
| CLK4 | phosphorylation down-regulates quantity by destabilization | MITF | SIGNOR-274116 |
| RPS6KA1 | phosphorylation down-regulates | MITF | SIGNOR-75034 |
| ERK1/2 | phosphorylation down-regulates | MITF | SIGNOR-249575 |
| RPS6K | phosphorylation down-regulates | MITF | SIGNOR-252795 |
| MAPK1 | phosphorylation down-regulates | MITF | SIGNOR-75030 |
| MAPK3 | phosphorylation down-regulates quantity by destabilization | MITF | SIGNOR-249620 |
| RPS6K | phosphorylation down-regulates | MITF | SIGNOR-252791 |
| RPS6KA1 | phosphorylation down-regulates | MITF | SIGNOR-174760 |
| GSK3B | phosphorylation → up-regulates activity | MITF | SIGNOR-275967 |
| GSK3B | phosphorylation → up-regulates quantity by stabilization | MITF | SIGNOR-276475 |
| GSK3B | phosphorylation → up-regulates quantity by stabilization | MITF | SIGNOR-276477 |
| PRKDC | phosphorylation → up-regulates activity | MITF | SIGNOR-277899 |
| GSK3A | phosphorylation → up-regulates | MITF | SIGNOR-72878 |
| Gbeta | phosphorylation down-regulates quantity by destabilization | MITF | SIGNOR-270029 |
| GSK3B | phosphorylation → up-regulates quantity by stabilization | MITF | SIGNOR-276476 |
| GSK3B | phosphorylation → up-regulates activity | MITF | SIGNOR-276356 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | MITF | SIGNOR-277281 |