Entity Details

Name ERK1/2_Ser180
ID O75030
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ERK1/2MITFSer180PGSSAPNsPMAMLTLphosphorylation
down-regulates		10673502SIGNOR-249575
MAPK1MITFSer180PGSSAPNsPMAMLTLphosphorylation
down-regulates		10673502SIGNOR-75030
MAPK3MITFSer180PGSSAPNsPMAMLTLphosphorylation
down-regulates quantity by destabilization		10841026SIGNOR-249620
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ERK1/2phosphorylation
up-regulates
→
MITF
PSer180		phosphorylation
down-regulates
⊣		MITF10673502SIGNOR-249575
MAPK1phosphorylation
up-regulates
→
MITF
PSer180		phosphorylation
down-regulates
⊣		MITF10673502SIGNOR-75030
MAPK3phosphorylation
up-regulates
→
MITF
PSer180		phosphorylation
down-regulates
⊣		MITF10841026SIGNOR-249620
Regulator Mechanism/Effect Target SIGNOR-ID
ERK1/2phosphorylation
img/direct_inhibition.png
down-regulates 		MITFSIGNOR-249575
MAPK1phosphorylation
img/direct_inhibition.png
down-regulates 		MITFSIGNOR-75030
MAPK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		MITFSIGNOR-249620