Entity Details

Name PTP4A3
ID O75365
Role phosphatase
Enzymatic Domains
Tyrosine-protein phosphatase 8-161
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTP4A3ITGB1Tyr783DTGENPIyKSAVTTVdephosphorylation
down-regulates activity		23092334SIGNOR-277050
PTP4A3KRT8Ser432SAYGGLTsPGLSYSLdephosphorylation
down-regulates activity		19115206SIGNOR-248341
PTP4A3KRT8Ser74TVNQSLLsPLVLEVDdephosphorylation
down-regulates activity		19115206SIGNOR-248340
PTP4A3EZRThr567QGRDKYKtLRQIRQGdephosphorylation
down-regulates activity		18078820SIGNOR-248342
PTP4A3PTEN–dephosphorylation
down-regulates quantity by destabilization		29266303SIGNOR-277010
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTP4A3dephosphorylation
down-regulates
⊣
ITGB1
PTyr783		dephosphorylation
up-regulates
→		ITGB123092334SIGNOR-277050
PTP4A3dephosphorylation
down-regulates
⊣
KRT8
PSer432		dephosphorylation
up-regulates
→		KRT819115206SIGNOR-248341
PTP4A3dephosphorylation
down-regulates
⊣
KRT8
PSer74		dephosphorylation
up-regulates
→		KRT819115206SIGNOR-248340
PTP4A3dephosphorylation
down-regulates
⊣
EZR
PThr567		dephosphorylation
up-regulates
→		EZR18078820SIGNOR-248342
Regulator Mechanism/Effect Target SIGNOR-ID
PTP4A3dephosphorylation
→
down-regulates activity 		ITGB1SIGNOR-277050
PTP4A3dephosphorylation
→
down-regulates activity 		KRT8SIGNOR-248341
PTP4A3dephosphorylation
→
down-regulates activity 		KRT8SIGNOR-248340
PTP4A3dephosphorylation
→
down-regulates activity 		EZRSIGNOR-248342
PTP4A3dephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		PTENSIGNOR-277010