| Name | ULK1 |
| ID | O75385 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 16-278 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ULK1 | DENND3 | Ser472 | THRRMVVsMPNLQDI | phosphorylation up-regulates activity | 25925668 | SIGNOR-264730 |
| ULK1 | DENND3 | Ser490 | ELAPRNSsLRLTDTA | phosphorylation up-regulates activity | 25925668 | SIGNOR-264731 |
| ULK1 | PRKN | Ser108 | SLTRVDLsSSVLPGD | phosphorylation up-regulates activity | 33827825 | SIGNOR-279663 |
| ULK1 | ATG13 | – | phosphorylation up-regulates | 19211835 | SIGNOR-183957 | |
| ULK1 | ENO1 | Ser115 | ANAILGVsLAVCKAG | phosphorylation down-regulates activity | 27153534 | SIGNOR-274030 |
| ULK1 | ENO1 | Ser282 | QLADLYKsFIKDYPV | phosphorylation down-regulates activity | 27153534 | SIGNOR-274029 |
| ULK1 | PFKM | Ser74 | EATWESVsMMLQLGG | phosphorylation down-regulates activity | 27153534 | SIGNOR-274035 |
| ULK1 | PFKM | Ser762 | YEIDLDTsDHAHLEH | phosphorylation down-regulates activity | 27153534 | SIGNOR-274036 |
| ULK1 | FBP1 | Ser63 | HLYGIAGsTNVTGDQ | phosphorylation down-regulates activity | 27153534 | SIGNOR-274032 |
| ULK1 | FBP1 | Ser88 | LVMNMLKsSFATCVL | phosphorylation down-regulates activity | 27153534 | SIGNOR-274031 |
| ULK1 | HK1 | Ser124 | NIVHGSGsQLFDHVA | phosphorylation up-regulates activity | 27153534 | SIGNOR-274034 |
| ULK1 | HK1 | Ser364 | TRLGVEPsDDDCVSV | phosphorylation up-regulates activity | 27153534 | SIGNOR-274033 |
| ULK1 | YAP1 | Ser227 | VQQNMMNsASGPLPD | phosphorylation up-regulates quantity by stabilization | 34345207 | SIGNOR-277570 |
| ULK1 | PRKAA2 | – | phosphorylation down-regulates | 21460634 | SIGNOR-173050 | |
| ULK1 | PRKAA1 | – | phosphorylation down-regulates activity | 21460634 | SIGNOR-173047 | |
| ULK1 | SQSTM1 | Ser403 | ESLSQMLsMGFSDEG | phosphorylation down-regulates quantity by destabilization | 25040165 | SIGNOR-278349 |
| ULK1 | BECN1 | – | phosphorylation up-regulates activity | 29671878 | SIGNOR-278503 | |
| ULK1 | SEC23B | Ser186 | SCEGISKsYVFRGTK | phosphorylation up-regulates quantity by stabilization | 30596474 | SIGNOR-265285 |
| ULK1 | CDC37 | Ser339 | HMQRCIDsGLWVPNS | phosphorylation down-regulates activity | 28073914 | SIGNOR-280158 |
| ULK1 | ATG14 | Ser29 | LARDLVDsVDDAEGL | phosphorylation up-regulates activity | 27938392 | SIGNOR-278433 |
| ULK1 | ATG9A | Ser761 | QSIPRSAsYPCAAPR | phosphorylation up-regulates activity | 25266655 | SIGNOR-266366 |
| ULK1 | ATG9A | Ser14 | EYQRLEAsYSDSPPG | phosphorylation up-regulates activity | 27934868 | SIGNOR-266369 |
| ULK1 | STING1 | Ser366 | QEPELLIsGMEKPLP | phosphorylation down-regulates activity | 24119841 | SIGNOR-279316 |
| ULK1 | FUNDC1 | Ser17 | DYESDDDsYEVLDLT | phosphorylation up-regulates activity | 24671035 | SIGNOR-273606 |
| ULK1 | FUNDC1 | Ser17 | DYESDDDsYEVLDLT | phosphorylation up-regulates activity | 27757847 | SIGNOR-279001 |
| ULK1 | RPTOR | Ser792 | DKMRRASsYSSLNSL | phosphorylation down-regulates activity | 25761126 | SIGNOR-278461 |
| ULK1 | PIK3C3 | – | phosphorylation up-regulates activity | 29671878 | SIGNOR-279670 | |
| ULK1 | RB1CC1 | – | phosphorylation up-regulates | 19597335 | SIGNOR-186992 | |
| ULK1 | AMBRA1 | – | phosphorylation up-regulates | 20921139 | SIGNOR-168292 | |
| ULK1 | PRKAG3 | – | phosphorylation down-regulates | 21460634 | SIGNOR-173053 | |
| ULK1 | ATG4B | Ser316 | SIAELDPsIAVGFFC | phosphorylation down-regulates activity | 28821708 | SIGNOR-279434 |
| ULK1 | AMPK | – | phosphorylation down-regulates | 21460634 | SIGNOR-217484 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ULK1 | phosphorylation up-regulates → | DENND3 PSer472 | phosphorylation up-regulates → | DENND3 | 25925668 | SIGNOR-264730 |
| ULK1 | phosphorylation up-regulates → | DENND3 PSer490 | phosphorylation up-regulates → | DENND3 | 25925668 | SIGNOR-264731 |
| ULK1 | phosphorylation up-regulates → | PRKN PSer108 | phosphorylation up-regulates → | PRKN | 33827825 | SIGNOR-279663 |
| ULK1 | phosphorylation up-regulates → | ENO1 PSer115 | phosphorylation down-regulates ⊣ | ENO1 | 27153534 | SIGNOR-274030 |
| ULK1 | phosphorylation up-regulates → | ENO1 PSer282 | phosphorylation down-regulates ⊣ | ENO1 | 27153534 | SIGNOR-274029 |
| ULK1 | phosphorylation up-regulates → | PFKM PSer74 | phosphorylation down-regulates ⊣ | PFKM | 27153534 | SIGNOR-274035 |
| ULK1 | phosphorylation up-regulates → | PFKM PSer762 | phosphorylation down-regulates ⊣ | PFKM | 27153534 | SIGNOR-274036 |
| ULK1 | phosphorylation up-regulates → | FBP1 PSer63 | phosphorylation down-regulates ⊣ | FBP1 | 27153534 | SIGNOR-274032 |
| ULK1 | phosphorylation up-regulates → | FBP1 PSer88 | phosphorylation down-regulates ⊣ | FBP1 | 27153534 | SIGNOR-274031 |
| ULK1 | phosphorylation up-regulates → | HK1 PSer124 | phosphorylation up-regulates → | HK1 | 27153534 | SIGNOR-274034 |
| ULK1 | phosphorylation up-regulates → | HK1 PSer364 | phosphorylation up-regulates → | HK1 | 27153534 | SIGNOR-274033 |
| ULK1 | phosphorylation up-regulates → | YAP1 PSer227 | phosphorylation up-regulates → | YAP1 | 34345207 | SIGNOR-277570 |
| ULK1 | phosphorylation up-regulates → | SQSTM1 PSer403 | phosphorylation down-regulates ⊣ | SQSTM1 | 25040165 | SIGNOR-278349 |
| ULK1 | phosphorylation up-regulates → | SEC23B PSer186 | phosphorylation up-regulates → | SEC23B | 30596474 | SIGNOR-265285 |
| ULK1 | phosphorylation up-regulates → | CDC37 PSer339 | phosphorylation down-regulates ⊣ | CDC37 | 28073914 | SIGNOR-280158 |
| ULK1 | phosphorylation up-regulates → | ATG14 PSer29 | phosphorylation up-regulates → | ATG14 | 27938392 | SIGNOR-278433 |
| ULK1 | phosphorylation up-regulates → | ATG9A PSer761 | phosphorylation up-regulates → | ATG9A | 25266655 | SIGNOR-266366 |
| ULK1 | phosphorylation up-regulates → | ATG9A PSer14 | phosphorylation up-regulates → | ATG9A | 27934868 | SIGNOR-266369 |
| ULK1 | phosphorylation up-regulates → | STING1 PSer366 | phosphorylation down-regulates ⊣ | STING1 | 24119841 | SIGNOR-279316 |
| ULK1 | phosphorylation up-regulates → | FUNDC1 PSer17 | phosphorylation up-regulates → | FUNDC1 | 24671035 | SIGNOR-273606 |
| ULK1 | phosphorylation up-regulates → | FUNDC1 PSer17 | phosphorylation up-regulates → | FUNDC1 | 27757847 | SIGNOR-279001 |
| ULK1 | phosphorylation up-regulates → | RPTOR PSer792 | phosphorylation down-regulates ⊣ | RPTOR | 25761126 | SIGNOR-278461 |
| ULK1 | phosphorylation up-regulates → | ATG4B PSer316 | phosphorylation down-regulates ⊣ | ATG4B | 28821708 | SIGNOR-279434 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ULK1 | phosphorylation → up-regulates activity | DENND3 | SIGNOR-264730 |
| ULK1 | phosphorylation → up-regulates activity | DENND3 | SIGNOR-264731 |
| ULK1 | phosphorylation → up-regulates activity | PRKN | SIGNOR-279663 |
| ULK1 | phosphorylation → up-regulates | ATG13 | SIGNOR-183957 |
| ULK1 | phosphorylation → down-regulates activity | ENO1 | SIGNOR-274030 |
| ULK1 | phosphorylation → down-regulates activity | ENO1 | SIGNOR-274029 |
| ULK1 | phosphorylation → down-regulates activity | PFKM | SIGNOR-274035 |
| ULK1 | phosphorylation → down-regulates activity | PFKM | SIGNOR-274036 |
| ULK1 | phosphorylation → down-regulates activity | FBP1 | SIGNOR-274032 |
| ULK1 | phosphorylation → down-regulates activity | FBP1 | SIGNOR-274031 |
| ULK1 | phosphorylation → up-regulates activity | HK1 | SIGNOR-274034 |
| ULK1 | phosphorylation → up-regulates activity | HK1 | SIGNOR-274033 |
| ULK1 | phosphorylation → up-regulates quantity by stabilization | YAP1 | SIGNOR-277570 |
| ULK1 | phosphorylation down-regulates | PRKAA2 | SIGNOR-173050 |
| ULK1 | phosphorylation → down-regulates activity | PRKAA1 | SIGNOR-173047 |
| ULK1 | phosphorylation down-regulates quantity by destabilization | SQSTM1 | SIGNOR-278349 |
| ULK1 | phosphorylation → up-regulates activity | BECN1 | SIGNOR-278503 |
| ULK1 | phosphorylation → up-regulates quantity by stabilization | SEC23B | SIGNOR-265285 |
| ULK1 | phosphorylation → down-regulates activity | CDC37 | SIGNOR-280158 |
| ULK1 | phosphorylation → up-regulates activity | ATG14 | SIGNOR-278433 |
| ULK1 | phosphorylation → up-regulates activity | ATG9A | SIGNOR-266366 |
| ULK1 | phosphorylation → up-regulates activity | ATG9A | SIGNOR-266369 |
| ULK1 | phosphorylation → down-regulates activity | STING1 | SIGNOR-279316 |
| ULK1 | phosphorylation → up-regulates activity | FUNDC1 | SIGNOR-273606 |
| ULK1 | phosphorylation → up-regulates activity | FUNDC1 | SIGNOR-279001 |
| ULK1 | phosphorylation → down-regulates activity | RPTOR | SIGNOR-278461 |
| ULK1 | phosphorylation → up-regulates activity | PIK3C3 | SIGNOR-279670 |
| ULK1 | phosphorylation → up-regulates | RB1CC1 | SIGNOR-186992 |
| ULK1 | phosphorylation → up-regulates | AMBRA1 | SIGNOR-168292 |
| ULK1 | phosphorylation down-regulates | PRKAG3 | SIGNOR-173053 |
| ULK1 | phosphorylation → down-regulates activity | ATG4B | SIGNOR-279434 |
| ULK1 | phosphorylation down-regulates | AMPK | SIGNOR-217484 |