| Name | ULK1 |
| ID | O75385 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 16-278 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | ULK1 | – | phosphorylation up-regulates | 21460634 | SIGNOR-216464 | |
| PRKAB1 | ULK1 | – | phosphorylation up-regulates | 21460634 | SIGNOR-173044 | |
| MTOR | ULK1 | Ser758 | PVVFTVGsPPSGSTP | phosphorylation down-regulates activity | 21383122 | SIGNOR-172541 |
| AMPK | ULK1 | Ser556 | GLGCRLHsAPNLSDL | phosphorylation up-regulates | 19584320 | SIGNOR-216495 |
| AMPK | ULK1 | Ser317 | SHLASPPsLGEMQQL | phosphorylation up-regulates | 19584320 | SIGNOR-216491 |
| MTOR | ULK1 | – | phosphorylation down-regulates activity | 19690328 | SIGNOR-187611 | |
| AMPK | ULK1 | Ser556 | GLGCRLHsAPNLSDL | phosphorylation up-regulates | 21205641 | SIGNOR-216457 |
| PRKAA2 | ULK1 | Ser556 | GLGCRLHsAPNLSDL | phosphorylation up-regulates | 19584320 | SIGNOR-186637 |
| PBK | ULK1 | Ser533 | AEMRGGRsPRPGSSA | phosphorylation down-regulates activity | 31378785 | SIGNOR-277472 |
| AMPK | ULK1 | Ser317 | SHLASPPsLGEMQQL | phosphorylation up-regulates | 21205641 | SIGNOR-216453 |
| PRKCA | ULK1 | Ser423 | GRAGPFSsSRCGASV | phosphorylation down-regulates quantity by destabilization | 35931119 | SIGNOR-277900 |
| STK38L | ULK1 | Ser495 | GVLARKMsLGGGRPY | phosphorylation down-regulates quantity | 35670107 | SIGNOR-270348 |
| AMPK | ULK1 | Ser638 | FDFPKTPsSQNLLAL | phosphorylation up-regulates | 19584320 | SIGNOR-216499 |
| AMPK | ULK1 | Ser638 | FDFPKTPsSQNLLAL | phosphorylation up-regulates | 21205641 | SIGNOR-216461 |
| PBK | ULK1 | Ser495 | GVLARKMsLGGGRPY | phosphorylation down-regulates activity | 31378785 | SIGNOR-277473 |
| PRKAA2 | ULK1 | Ser638 | FDFPKTPsSQNLLAL | phosphorylation up-regulates | 19584320 | SIGNOR-186641 |
| PRKAA1 | ULK1 | – | phosphorylation up-regulates activity | 21460634 | SIGNOR-173038 | |
| PRKCA | ULK1 | Ser423 | GRAGPFSsSRCGASV | phosphorylation down-regulates activity | 30154410 | SIGNOR-279558 |
| PBK | ULK1 | Ser469 | IRRSGSTsPLGFARA | phosphorylation down-regulates activity | 31378785 | SIGNOR-277474 |
| PRKAA2 | ULK1 | Ser638 | FDFPKTPsSQNLLAL | phosphorylation up-regulates | 21205641 | SIGNOR-170867 |
| MTOR | ULK1 | – | phosphorylation down-regulates activity | 21460634 | SIGNOR-183903 | |
| mTORC1 | ULK1 | – | phosphorylation down-regulates | 19690328 | SIGNOR-217133 | |
| PRKAA2 | ULK1 | Ser317 | SHLASPPsLGEMQQL | phosphorylation up-regulates | 19584320 | SIGNOR-186633 |
| PRKAA2 | ULK1 | Ser317 | SHLASPPsLGEMQQL | phosphorylation up-regulates | 21205641 | SIGNOR-170859 |
| PRKAA2 | ULK1 | Ser556 | GLGCRLHsAPNLSDL | phosphorylation up-regulates | 21205641 | SIGNOR-170863 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | phosphorylation up-regulates → | ULK1 PSer758 | phosphorylation down-regulates ⊣ | ULK1 | 21383122 | SIGNOR-172541 |
| AMPK | phosphorylation up-regulates → | ULK1 PSer556 | phosphorylation up-regulates → | ULK1 | 19584320 | SIGNOR-216495 |
| AMPK | phosphorylation up-regulates → | ULK1 PSer317 | phosphorylation up-regulates → | ULK1 | 19584320 | SIGNOR-216491 |
| AMPK | phosphorylation up-regulates → | ULK1 PSer556 | phosphorylation up-regulates → | ULK1 | 21205641 | SIGNOR-216457 |
| PRKAA2 | phosphorylation up-regulates → | ULK1 PSer556 | phosphorylation up-regulates → | ULK1 | 19584320 | SIGNOR-186637 |
| PBK | phosphorylation up-regulates → | ULK1 PSer533 | phosphorylation down-regulates ⊣ | ULK1 | 31378785 | SIGNOR-277472 |
| AMPK | phosphorylation up-regulates → | ULK1 PSer317 | phosphorylation up-regulates → | ULK1 | 21205641 | SIGNOR-216453 |
| PRKCA | phosphorylation up-regulates → | ULK1 PSer423 | phosphorylation down-regulates ⊣ | ULK1 | 35931119 | SIGNOR-277900 |
| STK38L | phosphorylation up-regulates → | ULK1 PSer495 | phosphorylation down-regulates ⊣ | ULK1 | 35670107 | SIGNOR-270348 |
| AMPK | phosphorylation up-regulates → | ULK1 PSer638 | phosphorylation up-regulates → | ULK1 | 19584320 | SIGNOR-216499 |
| AMPK | phosphorylation up-regulates → | ULK1 PSer638 | phosphorylation up-regulates → | ULK1 | 21205641 | SIGNOR-216461 |
| PBK | phosphorylation up-regulates → | ULK1 PSer495 | phosphorylation down-regulates ⊣ | ULK1 | 31378785 | SIGNOR-277473 |
| PRKAA2 | phosphorylation up-regulates → | ULK1 PSer638 | phosphorylation up-regulates → | ULK1 | 19584320 | SIGNOR-186641 |
| PRKCA | phosphorylation up-regulates → | ULK1 PSer423 | phosphorylation down-regulates ⊣ | ULK1 | 30154410 | SIGNOR-279558 |
| PBK | phosphorylation up-regulates → | ULK1 PSer469 | phosphorylation down-regulates ⊣ | ULK1 | 31378785 | SIGNOR-277474 |
| PRKAA2 | phosphorylation up-regulates → | ULK1 PSer638 | phosphorylation up-regulates → | ULK1 | 21205641 | SIGNOR-170867 |
| PRKAA2 | phosphorylation up-regulates → | ULK1 PSer317 | phosphorylation up-regulates → | ULK1 | 19584320 | SIGNOR-186633 |
| PRKAA2 | phosphorylation up-regulates → | ULK1 PSer317 | phosphorylation up-regulates → | ULK1 | 21205641 | SIGNOR-170859 |
| PRKAA2 | phosphorylation up-regulates → | ULK1 PSer556 | phosphorylation up-regulates → | ULK1 | 21205641 | SIGNOR-170863 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation → up-regulates | ULK1 | SIGNOR-216464 |
| PRKAB1 | phosphorylation → up-regulates | ULK1 | SIGNOR-173044 |
| MTOR | phosphorylation → down-regulates activity | ULK1 | SIGNOR-172541 |
| AMPK | phosphorylation → up-regulates | ULK1 | SIGNOR-216495 |
| AMPK | phosphorylation → up-regulates | ULK1 | SIGNOR-216491 |
| MTOR | phosphorylation → down-regulates activity | ULK1 | SIGNOR-187611 |
| AMPK | phosphorylation → up-regulates | ULK1 | SIGNOR-216457 |
| PRKAA2 | phosphorylation → up-regulates | ULK1 | SIGNOR-186637 |
| PBK | phosphorylation → down-regulates activity | ULK1 | SIGNOR-277472 |
| AMPK | phosphorylation → up-regulates | ULK1 | SIGNOR-216453 |
| PRKCA | phosphorylation down-regulates quantity by destabilization | ULK1 | SIGNOR-277900 |
| STK38L | phosphorylation → down-regulates quantity | ULK1 | SIGNOR-270348 |
| AMPK | phosphorylation → up-regulates | ULK1 | SIGNOR-216499 |
| AMPK | phosphorylation → up-regulates | ULK1 | SIGNOR-216461 |
| PBK | phosphorylation → down-regulates activity | ULK1 | SIGNOR-277473 |
| PRKAA2 | phosphorylation → up-regulates | ULK1 | SIGNOR-186641 |
| PRKAA1 | phosphorylation → up-regulates activity | ULK1 | SIGNOR-173038 |
| PRKCA | phosphorylation → down-regulates activity | ULK1 | SIGNOR-279558 |
| PBK | phosphorylation → down-regulates activity | ULK1 | SIGNOR-277474 |
| PRKAA2 | phosphorylation → up-regulates | ULK1 | SIGNOR-170867 |
| MTOR | phosphorylation → down-regulates activity | ULK1 | SIGNOR-183903 |
| mTORC1 | phosphorylation down-regulates | ULK1 | SIGNOR-217133 |
| PRKAA2 | phosphorylation → up-regulates | ULK1 | SIGNOR-186633 |
| PRKAA2 | phosphorylation → up-regulates | ULK1 | SIGNOR-170859 |
| PRKAA2 | phosphorylation → up-regulates | ULK1 | SIGNOR-170863 |