Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AURKC	TACC1	Ser228	ELVPSRRsKLRKPKP	phosphorylation up-regulates activity	21531210	SIGNOR-262663

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AURKC	phosphorylation up-regulates →	TACC1 PSer228	phosphorylation up-regulates →	TACC1	21531210	SIGNOR-262663

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AURKC	phosphorylation → up-regulates activity	TACC1	SIGNOR-262663