| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| VRK1 | BANF1 | Ser4 | sQKHRDFV | phosphorylation down-regulates | 16371512 | SIGNOR-143285 |
| VRK2 | BANF1 | Ser4 | sQKHRDFV | phosphorylation down-regulates | 16371512 | SIGNOR-143368 |
| VRK1 | BANF1 | Thr2 | tTSQKHRD | phosphorylation down-regulates | 16495336 | SIGNOR-144787 |
| PPP4C | BANF1 | Ser4 | sQKHRDFV | dephosphorylation up-regulates | 24265311 | SIGNOR-203281 |
| VRK1 | BANF1 | Thr3 | tSQKHRDF | phosphorylation down-regulates | 16495336 | SIGNOR-144791 |
| PPP4C | BANF1 | Ser4 | sQKHRDFV | dephosphorylation up-regulates | 16495336 | SIGNOR-144779 |
| VRK2 | BANF1 | Thr2 | tTSQKHRD | phosphorylation down-regulates | 16495336 | SIGNOR-144799 |
| VRK1 | BANF1 | Ser4 | sQKHRDFV | phosphorylation down-regulates | 16495336 | SIGNOR-144783 |
| VRK2 | BANF1 | Ser4 | sQKHRDFV | phosphorylation down-regulates | 16495336 | SIGNOR-144795 |
| VRK2 | BANF1 | Thr3 | tSQKHRDF | phosphorylation down-regulates | 16495336 | SIGNOR-144803 |
| VRK3 | BANF1 | Ser4 | sQKHRDFV | phosphorylation down-regulates activity | 25899223 | SIGNOR-264564 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| VRK1 | phosphorylation up-regulates → | BANF1 PSer4 | phosphorylation down-regulates ⊣ | BANF1 | 16371512 | SIGNOR-143285 |
| VRK2 | phosphorylation up-regulates → | BANF1 PSer4 | phosphorylation down-regulates ⊣ | BANF1 | 16371512 | SIGNOR-143368 |
| VRK1 | phosphorylation up-regulates → | BANF1 PThr2 | phosphorylation down-regulates ⊣ | BANF1 | 16495336 | SIGNOR-144787 |
| PPP4C | dephosphorylation down-regulates ⊣ | BANF1 PSer4 | dephosphorylation down-regulates ⊣ | BANF1 | 24265311 | SIGNOR-203281 |
| VRK1 | phosphorylation up-regulates → | BANF1 PThr3 | phosphorylation down-regulates ⊣ | BANF1 | 16495336 | SIGNOR-144791 |
| PPP4C | dephosphorylation down-regulates ⊣ | BANF1 PSer4 | dephosphorylation down-regulates ⊣ | BANF1 | 16495336 | SIGNOR-144779 |
| VRK2 | phosphorylation up-regulates → | BANF1 PThr2 | phosphorylation down-regulates ⊣ | BANF1 | 16495336 | SIGNOR-144799 |
| VRK1 | phosphorylation up-regulates → | BANF1 PSer4 | phosphorylation down-regulates ⊣ | BANF1 | 16495336 | SIGNOR-144783 |
| VRK2 | phosphorylation up-regulates → | BANF1 PSer4 | phosphorylation down-regulates ⊣ | BANF1 | 16495336 | SIGNOR-144795 |
| VRK2 | phosphorylation up-regulates → | BANF1 PThr3 | phosphorylation down-regulates ⊣ | BANF1 | 16495336 | SIGNOR-144803 |
| VRK3 | phosphorylation up-regulates → | BANF1 PSer4 | phosphorylation down-regulates ⊣ | BANF1 | 25899223 | SIGNOR-264564 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| VRK1 | phosphorylation down-regulates | BANF1 | SIGNOR-143285 |
| VRK2 | phosphorylation down-regulates | BANF1 | SIGNOR-143368 |
| VRK1 | phosphorylation down-regulates | BANF1 | SIGNOR-144787 |
| PPP4C | dephosphorylation → up-regulates | BANF1 | SIGNOR-203281 |
| VRK1 | phosphorylation down-regulates | BANF1 | SIGNOR-144791 |
| PPP4C | dephosphorylation → up-regulates | BANF1 | SIGNOR-144779 |
| VRK2 | phosphorylation down-regulates | BANF1 | SIGNOR-144799 |
| VRK1 | phosphorylation down-regulates | BANF1 | SIGNOR-144783 |
| VRK2 | phosphorylation down-regulates | BANF1 | SIGNOR-144795 |
| VRK2 | phosphorylation down-regulates | BANF1 | SIGNOR-144803 |
| VRK3 | phosphorylation → down-regulates activity | BANF1 | SIGNOR-264564 |
