| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | SF3B1 | Thr434 | PARKLTAtPTPLGGM | phosphorylation unknown | 16512921 | SIGNOR-144975 |
| CDK2 | SF3B1 | Thr313 | HGSGWAEtPRTDRGG | phosphorylation unknown | 12105215 | SIGNOR-90442 |
| CyclinE/CDK2 | SF3B1 | Thr244 | GRAKGSEtPGATPGS | phosphorylation up-regulates | 12105215 | SIGNOR-216686 |
| CyclinE/CDK2 | SF3B1 | Thr313 | HGSGWAEtPRTDRGG | phosphorylation unknown | 12105215 | SIGNOR-216717 |
| CyclinE/CDK2 | SF3B1 | Thr248 | GSETPGAtPGSKIWD | phosphorylation up-regulates | 12105215 | SIGNOR-216666 |
| CDK2 | SF3B1 | Thr244 | GRAKGSEtPGATPGS | phosphorylation up-regulates | 12105215 | SIGNOR-90434 |
| CDK2 | SF3B1 | Thr248 | GSETPGAtPGSKIWD | phosphorylation up-regulates | 12105215 | SIGNOR-90438 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | phosphorylation up-regulates → | SF3B1 PThr434 | phosphorylation down-regulates ⊣ | SF3B1 | 16512921 | SIGNOR-144975 |
| CDK2 | phosphorylation up-regulates → | SF3B1 PThr313 | phosphorylation down-regulates ⊣ | SF3B1 | 12105215 | SIGNOR-90442 |
| CyclinE/CDK2 | phosphorylation up-regulates → | SF3B1 PThr244 | phosphorylation up-regulates → | SF3B1 | 12105215 | SIGNOR-216686 |
| CyclinE/CDK2 | phosphorylation up-regulates → | SF3B1 PThr313 | phosphorylation down-regulates ⊣ | SF3B1 | 12105215 | SIGNOR-216717 |
| CyclinE/CDK2 | phosphorylation up-regulates → | SF3B1 PThr248 | phosphorylation up-regulates → | SF3B1 | 12105215 | SIGNOR-216666 |
| CDK2 | phosphorylation up-regulates → | SF3B1 PThr244 | phosphorylation up-regulates → | SF3B1 | 12105215 | SIGNOR-90434 |
| CDK2 | phosphorylation up-regulates → | SF3B1 PThr248 | phosphorylation up-regulates → | SF3B1 | 12105215 | SIGNOR-90438 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK1A | phosphorylation → unknown | SF3B1 | SIGNOR-144975 |
| CDK2 | phosphorylation → unknown | SF3B1 | SIGNOR-90442 |
| CyclinE/CDK2 | phosphorylation → up-regulates | SF3B1 | SIGNOR-216686 |
| CyclinE/CDK2 | phosphorylation → unknown | SF3B1 | SIGNOR-216717 |
| CyclinE/CDK2 | phosphorylation → up-regulates | SF3B1 | SIGNOR-216666 |
| CDK2 | phosphorylation → up-regulates | SF3B1 | SIGNOR-90434 |
| CDK2 | phosphorylation → up-regulates | SF3B1 | SIGNOR-90438 |
