Entity Details

Name IDH1
ID O75874
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CyclinA2/CDK2IDH1Thr157GKVEITYtPSDGTQKphosphorylation
down-regulates quantity by destabilization		34929314SIGNOR-267621
FLT3IDH1Tyr42VELDLHSyDLGIENRphosphorylation
up-regulates activity		34289383SIGNOR-267629
FLT3IDH1Tyr391
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PNVQRSDyLNTFEFMphosphorylation
up-regulates activity		34289383SIGNOR-267630
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CyclinA2/CDK2phosphorylation
up-regulates
→
IDH1
PThr157		phosphorylation
down-regulates
⊣		IDH134929314SIGNOR-267621
FLT3phosphorylation
up-regulates
→
IDH1
PTyr42		phosphorylation
up-regulates
→		IDH134289383SIGNOR-267629
FLT3phosphorylation
up-regulates
→
IDH1
PTyr391		phosphorylation
up-regulates
→		IDH134289383SIGNOR-267630
Regulator Mechanism/Effect Target SIGNOR-ID
CyclinA2/CDK2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		IDH1SIGNOR-267621
FLT3phosphorylation
→
up-regulates activity 		IDH1SIGNOR-267629
FLT3phosphorylation
→
up-regulates activity 		IDH1SIGNOR-267630