| Name | PAK3 |
| ID | O75914 |
| Role | kinase |
| Enzymatic Domains |
CRIB 70-83 PROSITE-ProRule
Protein kinase 283-534 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK3 | PAK3 | Ser154 | VNNQKYMsFTSGDKS | phosphorylation up-regulates activity | 11278486 | SIGNOR-250245 |
| PAK3 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates | 9823899 | SIGNOR-62043 |
| PAK3 | SYN1 | Ser605 | AGPTRQAsQAGPVPR | phosphorylation up-regulates activity | 12237306 | SIGNOR-250246 |
| PAK3 | TNNI3 | Ser150 | TLRRVRIsADAMMQA | phosphorylation down-regulates | 15769444 | SIGNOR-134593 |
| PAK3 | TNNI3 | Ser150 | TLRRVRIsADAMMQA | phosphorylation unknown | 12242269 | SIGNOR-92990 |
| PAK3 | CALD1 | Ser714 | EGVRNIKsMWEKGNV | phosphorylation down-regulates | 20858431 | SIGNOR-167976 |
| PAK3 | CALD1 | Ser744 | GLKVGVSsRINEWLT | phosphorylation down-regulates | 20858431 | SIGNOR-167980 |
| PAK3 | SORT1 | Ser793 | RFLVHRYsVLQQHAE | phosphorylation down-regulates activity | 31767632 | SIGNOR-273719 |
| PAK3 | MYO6 | Thr405 | TAGGTKGtVIKVPLK | phosphorylation up-regulates activity | 11517222 | SIGNOR-250244 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK3 | phosphorylation up-regulates → | PAK3 PSer154 | phosphorylation up-regulates → | PAK3 | 11278486 | SIGNOR-250245 |
| PAK3 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 9823899 | SIGNOR-62043 |
| PAK3 | phosphorylation up-regulates → | SYN1 PSer605 | phosphorylation up-regulates → | SYN1 | 12237306 | SIGNOR-250246 |
| PAK3 | phosphorylation up-regulates → | TNNI3 PSer150 | phosphorylation down-regulates ⊣ | TNNI3 | 15769444 | SIGNOR-134593 |
| PAK3 | phosphorylation up-regulates → | TNNI3 PSer150 | phosphorylation down-regulates ⊣ | TNNI3 | 12242269 | SIGNOR-92990 |
| PAK3 | phosphorylation up-regulates → | CALD1 PSer714 | phosphorylation down-regulates ⊣ | CALD1 | 20858431 | SIGNOR-167976 |
| PAK3 | phosphorylation up-regulates → | CALD1 PSer744 | phosphorylation down-regulates ⊣ | CALD1 | 20858431 | SIGNOR-167980 |
| PAK3 | phosphorylation up-regulates → | SORT1 PSer793 | phosphorylation down-regulates ⊣ | SORT1 | 31767632 | SIGNOR-273719 |
| PAK3 | phosphorylation up-regulates → | MYO6 PThr405 | phosphorylation up-regulates → | MYO6 | 11517222 | SIGNOR-250244 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK3 | phosphorylation → up-regulates activity | PAK3 | SIGNOR-250245 |
| PAK3 | phosphorylation → up-regulates | RAF1 | SIGNOR-62043 |
| PAK3 | phosphorylation → up-regulates activity | SYN1 | SIGNOR-250246 |
| PAK3 | phosphorylation down-regulates | TNNI3 | SIGNOR-134593 |
| PAK3 | phosphorylation → unknown | TNNI3 | SIGNOR-92990 |
| PAK3 | phosphorylation down-regulates | CALD1 | SIGNOR-167976 |
| PAK3 | phosphorylation down-regulates | CALD1 | SIGNOR-167980 |
| PAK3 | phosphorylation → down-regulates activity | SORT1 | SIGNOR-273719 |
| PAK3 | phosphorylation → up-regulates activity | MYO6 | SIGNOR-250244 |