| Name | PIAS1 |
| ID | O75925 |
| Role | substrate |
| Enzymatic Domains |
SAP 11-45 PROSITE-ProRule
PINIT 124-288 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | PIAS1 | Ser13 | ELKQMVMsLRVSELQ | phosphorylation down-regulates quantity by destabilization | 26157031 | SIGNOR-276924 |
| CSNK2A1 | PIAS1 | Ser466 | VIDLTIDsSSDEEEE | phosphorylation up-regulates | 19217413 | SIGNOR-184039 |
| CHUK | PIAS1 | Ser90 | SPMPATLsPSTIPQL | phosphorylation up-regulates activity | 17540171 | SIGNOR-278926 |
| CSNK2A1 | PIAS1 | Ser467 | IDLTIDSsSDEEEEE | phosphorylation up-regulates | 19217413 | SIGNOR-184043 |
| MAPKAPK2 | PIAS1 | Ser522 | DTSYINTsLIQDYRH | phosphorylation up-regulates | 23202365 | SIGNOR-199944 |
| GSK3B | PIAS1 | Ser17 | MVMSLRVsELQVLLG | phosphorylation down-regulates quantity by destabilization | 26157031 | SIGNOR-276923 |
| PRKAA1 | PIAS1 | Ser510 | SPVSRTPsLPAVDTS | phosphorylation up-regulates activity | 27256105 | SIGNOR-259866 |
| CSNK2A1 | PIAS1 | Ser468 | DLTIDSSsDEEEEEP | phosphorylation up-regulates | 19217413 | SIGNOR-184047 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | PIAS1 PSer13 | phosphorylation down-regulates ⊣ | PIAS1 | 26157031 | SIGNOR-276924 |
| CSNK2A1 | phosphorylation up-regulates → | PIAS1 PSer466 | phosphorylation up-regulates → | PIAS1 | 19217413 | SIGNOR-184039 |
| CHUK | phosphorylation up-regulates → | PIAS1 PSer90 | phosphorylation up-regulates → | PIAS1 | 17540171 | SIGNOR-278926 |
| CSNK2A1 | phosphorylation up-regulates → | PIAS1 PSer467 | phosphorylation up-regulates → | PIAS1 | 19217413 | SIGNOR-184043 |
| MAPKAPK2 | phosphorylation up-regulates → | PIAS1 PSer522 | phosphorylation up-regulates → | PIAS1 | 23202365 | SIGNOR-199944 |
| GSK3B | phosphorylation up-regulates → | PIAS1 PSer17 | phosphorylation down-regulates ⊣ | PIAS1 | 26157031 | SIGNOR-276923 |
| PRKAA1 | phosphorylation up-regulates → | PIAS1 PSer510 | phosphorylation up-regulates → | PIAS1 | 27256105 | SIGNOR-259866 |
| CSNK2A1 | phosphorylation up-regulates → | PIAS1 PSer468 | phosphorylation up-regulates → | PIAS1 | 19217413 | SIGNOR-184047 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates quantity by destabilization | PIAS1 | SIGNOR-276924 |
| CSNK2A1 | phosphorylation → up-regulates | PIAS1 | SIGNOR-184039 |
| CHUK | phosphorylation → up-regulates activity | PIAS1 | SIGNOR-278926 |
| CSNK2A1 | phosphorylation → up-regulates | PIAS1 | SIGNOR-184043 |
| MAPKAPK2 | phosphorylation → up-regulates | PIAS1 | SIGNOR-199944 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | PIAS1 | SIGNOR-276923 |
| PRKAA1 | phosphorylation → up-regulates activity | PIAS1 | SIGNOR-259866 |
| CSNK2A1 | phosphorylation → up-regulates | PIAS1 | SIGNOR-184047 |