Entity Details

Name TRIO
ID O75962
Role substrate
Enzymatic Domains
CRAL-TRIO 65-210
PROSITE-ProRule
DH 1 1292-1467
PROSITE-ProRule
PH 1 1480-1591
PROSITE-ProRule
SH3 1 1656-1721
PROSITE-ProRule
DH 2 1969-2145
PROSITE-ProRule
PH 2 2157-2271
PROSITE-ProRule
SH3 2 2551-2616
PROSITE-ProRule
Ig-like C2-type 2685-2775
Protein kinase 2796-3052
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
FYNTRIOTyr2681LLNPNYIyDVPPEFVphosphorylation
up-regulates activity		23230270SIGNOR-273855
CDK5TRIO–phosphorylation
up-regulates activity		15331630SIGNOR-280220
PTK2TRIOTyr2796KDNFDSFySEVAELGphosphorylation
up-regulates activity		12551902SIGNOR-249188
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
FYNphosphorylation
up-regulates
→
TRIO
PTyr2681		phosphorylation
up-regulates
→		TRIO23230270SIGNOR-273855
PTK2phosphorylation
up-regulates
→
TRIO
PTyr2796		phosphorylation
up-regulates
→		TRIO12551902SIGNOR-249188
Regulator Mechanism/Effect Target SIGNOR-ID
FYNphosphorylation
→
up-regulates activity 		TRIOSIGNOR-273855
CDK5phosphorylation
→
up-regulates activity 		TRIOSIGNOR-280220
PTK2phosphorylation
→
up-regulates activity 		TRIOSIGNOR-249188