Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDKL5	CDKL5	Thr169	EGNNANYtEYVATRW	phosphorylation up-regulates activity	16935860	SIGNOR-262289
CDKL5	CDKL5	Tyr171 View in OncoXplorer	NNANYTEyVATRWYR	phosphorylation up-regulates activity	16935860	SIGNOR-245876
CDKL5	SOX9	Ser199	ATEQTHIsPNAIFKA	phosphorylation down-regulates activity	32317630	SIGNOR-279457
CDKL5	AMPH	Ser293	PAPARPRsPSQTRKG	phosphorylation down-regulates activity	23651931	SIGNOR-245881
CDKL5	MECP2	–		phosphorylation unknown	16935860	SIGNOR-264702
CDKL5	LRRC4C	Ser631	PLLIRMNsKDNVQET	phosphorylation unknown	22922712	SIGNOR-192035

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDKL5	phosphorylation up-regulates →	CDKL5 PThr169	phosphorylation up-regulates →	CDKL5	16935860	SIGNOR-262289
CDKL5	phosphorylation up-regulates →	CDKL5 PTyr171	phosphorylation up-regulates →	CDKL5	16935860	SIGNOR-245876
CDKL5	phosphorylation up-regulates →	SOX9 PSer199	phosphorylation down-regulates ⊣	SOX9	32317630	SIGNOR-279457
CDKL5	phosphorylation up-regulates →	AMPH PSer293	phosphorylation down-regulates ⊣	AMPH	23651931	SIGNOR-245881
CDKL5	phosphorylation up-regulates →	LRRC4C PSer631	phosphorylation down-regulates ⊣	LRRC4C	22922712	SIGNOR-192035

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDKL5	phosphorylation → up-regulates activity	CDKL5	SIGNOR-262289
CDKL5	phosphorylation → up-regulates activity	CDKL5	SIGNOR-245876
CDKL5	phosphorylation → down-regulates activity	SOX9	SIGNOR-279457
CDKL5	phosphorylation → down-regulates activity	AMPH	SIGNOR-245881
CDKL5	phosphorylation → unknown	MECP2	SIGNOR-264702
CDKL5	phosphorylation → unknown	LRRC4C	SIGNOR-192035