| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | TPPP | Ser18 | ANRTPPKsPGDPSKD | phosphorylation down-regulates activity | 17693641 | SIGNOR-262929 |
| CDK5 | TPPP | Ser18 | ANRTPPKsPGDPSKD | phosphorylation down-regulates activity | 17693641 | SIGNOR-262932 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | TPPP PSer18 | phosphorylation down-regulates ⊣ | TPPP | 17693641 | SIGNOR-262929 |
| CDK5 | phosphorylation up-regulates → | TPPP PSer18 | phosphorylation down-regulates ⊣ | TPPP | 17693641 | SIGNOR-262932 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → down-regulates activity | TPPP | SIGNOR-262929 |
| CDK5 | phosphorylation → down-regulates activity | TPPP | SIGNOR-262932 |