Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PTPN6	NFAT5	Tyr143	PKRHTVLyISPPPED	dephosphorylation down-regulates activity	20351292	SIGNOR-248467
ATM	NFAT5	Ser1367	LVQGSPSsQEQQVTL	phosphorylation up-regulates	15173573	SIGNOR-125081
ATM	NFAT5	Ser1247	AMQSNSPsQEQQQQQ	phosphorylation up-regulates	15173573	SIGNOR-125077
CSNK1A1L	NFAT5	Ser158	LLDNSRMsCQDEGCG	phosphorylation up-regulates activity	18411282	SIGNOR-274111
CDK1	NFAT5	Thr135 View in OncoXplorer	TVQQHPStPKRHTVL	phosphorylation up-regulates	21209322	SIGNOR-170882
CDK5	NFAT5	Thr135 View in OncoXplorer	TVQQHPStPKRHTVL	phosphorylation up-regulates	21209322	SIGNOR-170886
ATM	NFAT5	Ser1197	HIQTPMLsQEQAQPP	phosphorylation up-regulates	15173573	SIGNOR-125073

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PTPN6	dephosphorylation down-regulates ⊣	NFAT5 PTyr143	dephosphorylation up-regulates →	NFAT5	20351292	SIGNOR-248467
ATM	phosphorylation up-regulates →	NFAT5 PSer1367	phosphorylation up-regulates →	NFAT5	15173573	SIGNOR-125081
ATM	phosphorylation up-regulates →	NFAT5 PSer1247	phosphorylation up-regulates →	NFAT5	15173573	SIGNOR-125077
CSNK1A1L	phosphorylation up-regulates →	NFAT5 PSer158	phosphorylation up-regulates →	NFAT5	18411282	SIGNOR-274111
CDK1	phosphorylation up-regulates →	NFAT5 PThr135	phosphorylation up-regulates →	NFAT5	21209322	SIGNOR-170882
CDK5	phosphorylation up-regulates →	NFAT5 PThr135	phosphorylation up-regulates →	NFAT5	21209322	SIGNOR-170886
ATM	phosphorylation up-regulates →	NFAT5 PSer1197	phosphorylation up-regulates →	NFAT5	15173573	SIGNOR-125073

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PTPN6	dephosphorylation → down-regulates activity	NFAT5	SIGNOR-248467
ATM	phosphorylation → up-regulates	NFAT5	SIGNOR-125081
ATM	phosphorylation → up-regulates	NFAT5	SIGNOR-125077
CSNK1A1L	phosphorylation → up-regulates activity	NFAT5	SIGNOR-274111
CDK1	phosphorylation → up-regulates	NFAT5	SIGNOR-170882
CDK5	phosphorylation → up-regulates	NFAT5	SIGNOR-170886
ATM	phosphorylation → up-regulates	NFAT5	SIGNOR-125073