Entity Details

Name MFN2
ID O95140
Role substrate
Enzymatic Domains
Dynamin-type G 93-342
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PKAMFN2Ser442AEEIRRLSVLVDDYQphosphorylation
up-regulates activity		20303493SIGNOR-274137
MAPK9MFN2Ser27HMAEVNAsPLKHFVTphosphorylation
down-regulates		22748923SIGNOR-198054
MAPK8MFN2Ser27HMAEVNASPLKHFVTphosphorylation
down-regulates quantity		22748923SIGNOR-274138
PINK1MFN2Ser442AEEIRRLsVLVDDYQphosphorylation
down-regulates quantity		34275172SIGNOR-278208
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PKAphosphorylation
up-regulates
→
MFN2
PSer442		phosphorylation
up-regulates
→		MFN220303493SIGNOR-274137
MAPK9phosphorylation
up-regulates
→
MFN2
PSer27		phosphorylation
down-regulates
⊣		MFN222748923SIGNOR-198054
MAPK8phosphorylation
up-regulates
→
MFN2
PSer27		phosphorylation
down-regulates
⊣		MFN222748923SIGNOR-274138
PINK1phosphorylation
up-regulates
→
MFN2
PSer442		phosphorylation
down-regulates
⊣		MFN234275172SIGNOR-278208
Regulator Mechanism/Effect Target SIGNOR-ID
PKAphosphorylation
→
up-regulates activity 		MFN2SIGNOR-274137
MAPK9phosphorylation
img/direct_inhibition.png
down-regulates 		MFN2SIGNOR-198054
MAPK8phosphorylation
→
down-regulates quantity 		MFN2SIGNOR-274138
PINK1phosphorylation
→
down-regulates quantity 		MFN2SIGNOR-278208