Entity Details

Name SPDEF
ID O95238
Role substrate
Enzymatic Domains
PNT 129-213
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CyclinD3/CDK11ASPDEFSer238SEESWTDsEVDSSCSphosphorylation
down-regulates quantity by destabilization		26885618SIGNOR-273121
CDK11ASPDEFSer243TDSEVDSsCSGQPIHphosphorylation
down-regulates quantity by destabilization		26885618SIGNOR-273022
CDK11ASPDEFSer238SEESWTDsEVDSSCSphosphorylation
down-regulates quantity by destabilization		26885618SIGNOR-273020
CyclinD3/CDK11BSPDEFSer243TDSEVDSsCSGQPIHphosphorylation
down-regulates quantity by destabilization		26885618SIGNOR-273128
CyclinD3/CDK11ASPDEFSer242WTDSEVDsSCSGQPIphosphorylation
down-regulates quantity by destabilization		26885618SIGNOR-273122
CDK11ASPDEFSer242WTDSEVDsSCSGQPIphosphorylation
down-regulates quantity by destabilization		26885618SIGNOR-273021
CyclinD3/CDK11ASPDEFSer243TDSEVDSsCSGQPIHphosphorylation
down-regulates quantity by destabilization		26885618SIGNOR-273123
CyclinD3/CDK11BSPDEFSer238SEESWTDsEVDSSCSphosphorylation
down-regulates quantity by destabilization		26885618SIGNOR-273126
CyclinD3/CDK11BSPDEFSer242WTDSEVDsSCSGQPIphosphorylation
down-regulates quantity by destabilization		26885618SIGNOR-273127
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CyclinD3/CDK11Aphosphorylation
up-regulates
→
SPDEF
PSer238		phosphorylation
down-regulates
⊣		SPDEF26885618SIGNOR-273121
CDK11Aphosphorylation
up-regulates
→
SPDEF
PSer243		phosphorylation
down-regulates
⊣		SPDEF26885618SIGNOR-273022
CDK11Aphosphorylation
up-regulates
→
SPDEF
PSer238		phosphorylation
down-regulates
⊣		SPDEF26885618SIGNOR-273020
CyclinD3/CDK11Bphosphorylation
up-regulates
→
SPDEF
PSer243		phosphorylation
down-regulates
⊣		SPDEF26885618SIGNOR-273128
CyclinD3/CDK11Aphosphorylation
up-regulates
→
SPDEF
PSer242		phosphorylation
down-regulates
⊣		SPDEF26885618SIGNOR-273122
CDK11Aphosphorylation
up-regulates
→
SPDEF
PSer242		phosphorylation
down-regulates
⊣		SPDEF26885618SIGNOR-273021
CyclinD3/CDK11Aphosphorylation
up-regulates
→
SPDEF
PSer243		phosphorylation
down-regulates
⊣		SPDEF26885618SIGNOR-273123
CyclinD3/CDK11Bphosphorylation
up-regulates
→
SPDEF
PSer238		phosphorylation
down-regulates
⊣		SPDEF26885618SIGNOR-273126
CyclinD3/CDK11Bphosphorylation
up-regulates
→
SPDEF
PSer242		phosphorylation
down-regulates
⊣		SPDEF26885618SIGNOR-273127
Regulator Mechanism/Effect Target SIGNOR-ID
CyclinD3/CDK11Aphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SPDEFSIGNOR-273121
CDK11Aphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SPDEFSIGNOR-273022
CDK11Aphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SPDEFSIGNOR-273020
CyclinD3/CDK11Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SPDEFSIGNOR-273128
CyclinD3/CDK11Aphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SPDEFSIGNOR-273122
CDK11Aphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SPDEFSIGNOR-273021
CyclinD3/CDK11Aphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SPDEFSIGNOR-273123
CyclinD3/CDK11Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SPDEFSIGNOR-273126
CyclinD3/CDK11Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SPDEFSIGNOR-273127