| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD3/CDK11B | SPDEF | Ser238 | SEESWTDsEVDSSCS | phosphorylation down-regulates quantity by destabilization | 26885618 | SIGNOR-273126 |
| CyclinD3/CDK11A | SPDEF | Ser238 | SEESWTDsEVDSSCS | phosphorylation down-regulates quantity by destabilization | 26885618 | SIGNOR-273121 |
| CDK11A | SPDEF | Ser238 | SEESWTDsEVDSSCS | phosphorylation down-regulates quantity by destabilization | 26885618 | SIGNOR-273020 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD3/CDK11B | phosphorylation up-regulates → | SPDEF PSer238 | phosphorylation down-regulates ⊣ | SPDEF | 26885618 | SIGNOR-273126 |
| CyclinD3/CDK11A | phosphorylation up-regulates → | SPDEF PSer238 | phosphorylation down-regulates ⊣ | SPDEF | 26885618 | SIGNOR-273121 |
| CDK11A | phosphorylation up-regulates → | SPDEF PSer238 | phosphorylation down-regulates ⊣ | SPDEF | 26885618 | SIGNOR-273020 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinD3/CDK11B | phosphorylation![]() down-regulates quantity by destabilization | SPDEF | SIGNOR-273126 |
| CyclinD3/CDK11A | phosphorylation![]() down-regulates quantity by destabilization | SPDEF | SIGNOR-273121 |
| CDK11A | phosphorylation![]() down-regulates quantity by destabilization | SPDEF | SIGNOR-273020 |