| Name | MBD4 |
| ID | O95243 |
| Role | substrate |
| Enzymatic Domains |
MBD 76-148 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK7 | MBD4 | – | phosphorylation down-regulates activity | 31466944 | SIGNOR-279686 | |
| PRKCA | MBD4 | Ser262 | SGFVQSDsKRESVCN | phosphorylation up-regulates activity | 23195996 | SIGNOR-275672 |
| PKC | MBD4 | Ser262 | SGFVQSDsKRESVCN | phosphorylation up-regulates activity | 23195996 | SIGNOR-275674 |
| PKC | MBD4 | Ser165 | CSMAALTsHLQNQSN | phosphorylation up-regulates activity | 23195996 | SIGNOR-275675 |
| PRKCA | MBD4 | Ser165 | CSMAALTsHLQNQSN | phosphorylation up-regulates activity | 23195996 | SIGNOR-275673 |
| ERBB2 | MBD4 | – | phosphorylation up-regulates activity | 22964581 | SIGNOR-279408 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | MBD4 PSer262 | phosphorylation up-regulates → | MBD4 | 23195996 | SIGNOR-275672 |
| PKC | phosphorylation up-regulates → | MBD4 PSer262 | phosphorylation up-regulates → | MBD4 | 23195996 | SIGNOR-275674 |
| PKC | phosphorylation up-regulates → | MBD4 PSer165 | phosphorylation up-regulates → | MBD4 | 23195996 | SIGNOR-275675 |
| PRKCA | phosphorylation up-regulates → | MBD4 PSer165 | phosphorylation up-regulates → | MBD4 | 23195996 | SIGNOR-275673 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK7 | phosphorylation → down-regulates activity | MBD4 | SIGNOR-279686 |
| PRKCA | phosphorylation → up-regulates activity | MBD4 | SIGNOR-275672 |
| PKC | phosphorylation → up-regulates activity | MBD4 | SIGNOR-275674 |
| PKC | phosphorylation → up-regulates activity | MBD4 | SIGNOR-275675 |
| PRKCA | phosphorylation → up-regulates activity | MBD4 | SIGNOR-275673 |
| ERBB2 | phosphorylation → up-regulates activity | MBD4 | SIGNOR-279408 |