Entity Details

Name MAP3K6
ID O95382
Role kinase
Enzymatic Domains
Protein kinase 648-906
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAP3K6MAP3K6Thr806GITPCTEtFTGTLQYphosphorylation
up-regulates activity		17210579SIGNOR-260774
MAP3K6MAPK14Thr180RHTDDEMtGYVATRWphosphorylation
up-regulates activity		8622669SIGNOR-260915
MAP3K6MAPK14Tyr182RHTDDEMtGYVATRWphosphorylation
up-regulates activity		8622669SIGNOR-260916
MAP3K6MAP3K5Thr838GINPCTEtFTGTLQYphosphorylation
up-regulates activity		17210579SIGNOR-260773
MAP3K6MAP3K5Thr838GINPCTEtFTGTLQYphosphorylation
up-regulates quantity by stabilization		17210579SIGNOR-260832
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAP3K6phosphorylation
up-regulates
→
MAP3K6
PThr806		phosphorylation
up-regulates
→		MAP3K617210579SIGNOR-260774
MAP3K6phosphorylation
up-regulates
→
MAPK14
PThr180		phosphorylation
up-regulates
→		MAPK148622669SIGNOR-260915
MAP3K6phosphorylation
up-regulates
→
MAPK14
PTyr182		phosphorylation
up-regulates
→		MAPK148622669SIGNOR-260916
MAP3K6phosphorylation
up-regulates
→
MAP3K5
PThr838		phosphorylation
up-regulates
→		MAP3K517210579SIGNOR-260773
MAP3K6phosphorylation
up-regulates
→
MAP3K5
PThr838		phosphorylation
up-regulates
→		MAP3K517210579SIGNOR-260832
Regulator Mechanism/Effect Target SIGNOR-ID
MAP3K6phosphorylation
→
up-regulates activity 		MAP3K6SIGNOR-260774
MAP3K6phosphorylation
→
up-regulates activity 		MAPK14SIGNOR-260915
MAP3K6phosphorylation
→
up-regulates activity 		MAPK14SIGNOR-260916
MAP3K6phosphorylation
→
up-regulates activity 		MAP3K5SIGNOR-260773
MAP3K6phosphorylation
→
up-regulates quantity by stabilization 		MAP3K5SIGNOR-260832