Entity Details

Name ABCA1
ID O95477
Role substrate
Enzymatic Domains
ABC transporter 1 899-1131
PROSITE-ProRule
ABC transporter 2 1912-2144
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKACAABCA1Ser2054GGNKRKLsTAMALIGphosphorylation
up-regulates activity		12196520SIGNOR-250327
PRKACAABCA1Ser1042GGMQRKLsVALAFVGphosphorylation
up-regulates activity		12196520SIGNOR-250326
EGFRABCA1Ser2054GGNKRKLsTAMALIGphosphorylation
down-regulates quantity by destabilization		12196520SIGNOR-264419
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKACAphosphorylation
up-regulates
→
ABCA1
PSer2054		phosphorylation
up-regulates
→		ABCA112196520SIGNOR-250327
PRKACAphosphorylation
up-regulates
→
ABCA1
PSer1042		phosphorylation
up-regulates
→		ABCA112196520SIGNOR-250326
EGFRphosphorylation
up-regulates
→
ABCA1
PSer2054		phosphorylation
down-regulates
⊣		ABCA112196520SIGNOR-264419
Regulator Mechanism/Effect Target SIGNOR-ID
PRKACAphosphorylation
→
up-regulates activity 		ABCA1SIGNOR-250327
PRKACAphosphorylation
→
up-regulates activity 		ABCA1SIGNOR-250326
EGFRphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ABCA1SIGNOR-264419