| Name | DDX58 |
| ID | O95786 |
| Role | substrate |
| Enzymatic Domains |
CARD 1 1-87
CARD 2 92-172
Helicase ATP-binding 251-430 PROSITE-ProRule
Helicase C-terminal 610-776 PROSITE-ProRule
RLR CTR 794-925 PROSITE-ProRule |
View in  |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | DDX58 | Thr770 | DSILRLQtWDEAVFR | phosphorylation down-regulates | 21068236 | SIGNOR-169408 |
| PPP1CA | DDX58 | Ser8 | MTTEQRRsLQAFQDY | dephosphorylation up-regulates activity | 23499489 | SIGNOR-264581 |
| DAPK1 | DDX58 | Ser8 | MTTEQRRsLQAFQDY | phosphorylation down-regulates activity | 30985869 | SIGNOR-279519 |
| PPP1CC | DDX58 | Ser8 | MTTEQRRsLQAFQDY | dephosphorylation up-regulates activity | 23499489 | SIGNOR-264580 |
| DAPK1 | DDX58 | Thr667 | ILTGRGKtNQNTGMT | phosphorylation down-regulates activity | 28132841 | SIGNOR-277336 |
| CSNK2A1 | DDX58 | Ser855 | PKPKQFSsFEKRAKI | phosphorylation down-regulates | 21068236 | SIGNOR-169404 |
| CSNK2A2 | DDX58 | Thr770 | DSILRLQtWDEAVFR | phosphorylation down-regulates activity | 21068236 | SIGNOR-276285 |
| CSNK2A1 | DDX58 | Ser854 | HPKPKQFsSFEKRAK | phosphorylation down-regulates | 21068236 | SIGNOR-169400 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | DDX58 PThr770 | phosphorylation down-regulates ⊣ | DDX58 | 21068236 | SIGNOR-169408 |
| PPP1CA | dephosphorylation down-regulates ⊣ | DDX58 PSer8 | dephosphorylation down-regulates ⊣ | DDX58 | 23499489 | SIGNOR-264581 |
| DAPK1 | phosphorylation up-regulates → | DDX58 PSer8 | phosphorylation down-regulates ⊣ | DDX58 | 30985869 | SIGNOR-279519 |
| PPP1CC | dephosphorylation down-regulates ⊣ | DDX58 PSer8 | dephosphorylation down-regulates ⊣ | DDX58 | 23499489 | SIGNOR-264580 |
| DAPK1 | phosphorylation up-regulates → | DDX58 PThr667 | phosphorylation down-regulates ⊣ | DDX58 | 28132841 | SIGNOR-277336 |
| CSNK2A1 | phosphorylation up-regulates → | DDX58 PSer855 | phosphorylation down-regulates ⊣ | DDX58 | 21068236 | SIGNOR-169404 |
| CSNK2A2 | phosphorylation up-regulates → | DDX58 PThr770 | phosphorylation down-regulates ⊣ | DDX58 | 21068236 | SIGNOR-276285 |
| CSNK2A1 | phosphorylation up-regulates → | DDX58 PSer854 | phosphorylation down-regulates ⊣ | DDX58 | 21068236 | SIGNOR-169400 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation down-regulates | DDX58 | SIGNOR-169408 |
| PPP1CA | dephosphorylation → up-regulates activity | DDX58 | SIGNOR-264581 |
| DAPK1 | phosphorylation → down-regulates activity | DDX58 | SIGNOR-279519 |
| PPP1CC | dephosphorylation → up-regulates activity | DDX58 | SIGNOR-264580 |
| DAPK1 | phosphorylation → down-regulates activity | DDX58 | SIGNOR-277336 |
| CSNK2A1 | phosphorylation down-regulates | DDX58 | SIGNOR-169404 |
| CSNK2A2 | phosphorylation → down-regulates activity | DDX58 | SIGNOR-276285 |
| CSNK2A1 | phosphorylation down-regulates | DDX58 | SIGNOR-169400 |