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Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAP4K4	PIK3CA	Thr1061	KMDWIFHtIKQHALN	phosphorylation down-regulates activity	38060450	SIGNOR-277921
MAP4K4	TRAF2	Ser35	LEAKYLCsACRNVLR	phosphorylation down-regulates quantity	25098764	SIGNOR-279536
MAP4K4	MAP3K1	–		phosphorylation up-regulates	8824585	SIGNOR-44040
MAP4K4	SMAD1	Thr322	SNVNRNStIENTRRH	phosphorylation down-regulates activity	21690388	SIGNOR-276335
MAP4K4	MAP3K11	Thr738	EEEPRGGtVSPPPGT	phosphorylation up-regulates activity	34511598	SIGNOR-277571
MAP4K4		–		phosphorylation up-regulates activity	25490267	SIGNOR-280020

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAP4K4	phosphorylation up-regulates →	PIK3CA PThr1061	phosphorylation down-regulates ⊣	PIK3CA	38060450	SIGNOR-277921
MAP4K4	phosphorylation up-regulates →	TRAF2 PSer35	phosphorylation down-regulates ⊣	TRAF2	25098764	SIGNOR-279536
MAP4K4	phosphorylation up-regulates →	SMAD1 PThr322	phosphorylation down-regulates ⊣	SMAD1	21690388	SIGNOR-276335
MAP4K4	phosphorylation up-regulates →	MAP3K11 PThr738	phosphorylation up-regulates →	MAP3K11	34511598	SIGNOR-277571

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAP4K4	phosphorylation → down-regulates activity	PIK3CA	SIGNOR-277921
MAP4K4	phosphorylation → down-regulates quantity	TRAF2	SIGNOR-279536
MAP4K4	phosphorylation → up-regulates	MAP3K1	SIGNOR-44040
MAP4K4	phosphorylation → down-regulates activity	SMAD1	SIGNOR-276335
MAP4K4	phosphorylation → up-regulates activity	MAP3K11	SIGNOR-277571
MAP4K4	phosphorylation → up-regulates activity		SIGNOR-280020