| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK6 | AIFM1 | Thr281 | GAEVKSRtTLFRKIG | phosphorylation down-regulates activity | 33867848 | SIGNOR-278969 |
| PAK5 | AIFM1 | Thr281 | GAEVKSRtTLFRKIG | phosphorylation down-regulates activity | 33867848 | SIGNOR-279085 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK6 | phosphorylation up-regulates → | AIFM1 PThr281 | phosphorylation down-regulates ⊣ | AIFM1 | 33867848 | SIGNOR-278969 |
| PAK5 | phosphorylation up-regulates → | AIFM1 PThr281 | phosphorylation down-regulates ⊣ | AIFM1 | 33867848 | SIGNOR-279085 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK6 | phosphorylation → down-regulates activity | AIFM1 | SIGNOR-278969 |
| PAK5 | phosphorylation → down-regulates activity | AIFM1 | SIGNOR-279085 |