Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
LATS1	PPP1R12A	Ser445	LGLRKTGsYGALAEI	phosphorylation up-regulates activity	22641346	SIGNOR-278184
LATS1	PPP1R12A	Ser473	GVTRSASsPRLSSSL	phosphorylation up-regulates activity	22641346	SIGNOR-278185
LATS1	PRPS2	Thr285	EDKMKHCtKIQVIDI	phosphorylation down-regulates quantity by destabilization	34465890	SIGNOR-276506
LATS1	YAP1	Ser127	PQHVRAHsSPASLQL	phosphorylation down-regulates	22658639	SIGNOR-197647
LATS1	YAP1	Ser397	TYHSRDEsTDSGLSM	phosphorylation down-regulates quantity by destabilization	20048001	SIGNOR-218034
LATS1	FOXL2	–		phosphorylation up-regulates activity	20407010	SIGNOR-279624
LATS1	PRPS1	Ser285	EDKMKHCsKIQVIDI	phosphorylation down-regulates quantity by destabilization	34465890	SIGNOR-276505
LATS1	MTF1	Ser152	EGCPRTYsTAGNLRT	phosphorylation down-regulates activity	35027733	SIGNOR-275473
LATS1	TAZ	–		phosphorylation down-regulates activity	25592648	SIGNOR-279200
LATS1	AMOT	Ser175	QGHVRSLsERLMQMS	phosphorylation up-regulates quantity by stabilization	24101513	SIGNOR-275843
LATS1	CDC26	Thr7	tRLELKLD	phosphorylation up-regulates activity	25723520	SIGNOR-275472
LATS1	WWTR1	Ser89	AQHVRSHsSPASLQL	phosphorylation down-regulates	21808241	SIGNOR-175783
LATS1	WWTR1	Ser89	AQHVRSHsSPASLQL	phosphorylation down-regulates	22658639	SIGNOR-197643

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
LATS1	phosphorylation up-regulates →	PPP1R12A PSer445	phosphorylation up-regulates →	PPP1R12A	22641346	SIGNOR-278184
LATS1	phosphorylation up-regulates →	PPP1R12A PSer473	phosphorylation up-regulates →	PPP1R12A	22641346	SIGNOR-278185
LATS1	phosphorylation up-regulates →	PRPS2 PThr285	phosphorylation down-regulates ⊣	PRPS2	34465890	SIGNOR-276506
LATS1	phosphorylation up-regulates →	YAP1 PSer127	phosphorylation down-regulates ⊣	YAP1	22658639	SIGNOR-197647
LATS1	phosphorylation up-regulates →	YAP1 PSer397	phosphorylation down-regulates ⊣	YAP1	20048001	SIGNOR-218034
LATS1	phosphorylation up-regulates →	PRPS1 PSer285	phosphorylation down-regulates ⊣	PRPS1	34465890	SIGNOR-276505
LATS1	phosphorylation up-regulates →	MTF1 PSer152	phosphorylation down-regulates ⊣	MTF1	35027733	SIGNOR-275473
LATS1	phosphorylation up-regulates →	AMOT PSer175	phosphorylation up-regulates →	AMOT	24101513	SIGNOR-275843
LATS1	phosphorylation up-regulates →	CDC26 PThr7	phosphorylation up-regulates →	CDC26	25723520	SIGNOR-275472
LATS1	phosphorylation up-regulates →	WWTR1 PSer89	phosphorylation down-regulates ⊣	WWTR1	21808241	SIGNOR-175783
LATS1	phosphorylation up-regulates →	WWTR1 PSer89	phosphorylation down-regulates ⊣	WWTR1	22658639	SIGNOR-197643

Regulator	Mechanism/Effect	Target	SIGNOR-ID
LATS1	phosphorylation → up-regulates activity	PPP1R12A	SIGNOR-278184
LATS1	phosphorylation → up-regulates activity	PPP1R12A	SIGNOR-278185
LATS1	phosphorylation down-regulates quantity by destabilization	PRPS2	SIGNOR-276506
LATS1	phosphorylation down-regulates	YAP1	SIGNOR-197647
LATS1	phosphorylation down-regulates quantity by destabilization	YAP1	SIGNOR-218034
LATS1	phosphorylation → up-regulates activity	FOXL2	SIGNOR-279624
LATS1	phosphorylation down-regulates quantity by destabilization	PRPS1	SIGNOR-276505
LATS1	phosphorylation → down-regulates activity	MTF1	SIGNOR-275473
LATS1	phosphorylation → down-regulates activity	TAZ	SIGNOR-279200
LATS1	phosphorylation → up-regulates quantity by stabilization	AMOT	SIGNOR-275843
LATS1	phosphorylation → up-regulates activity	CDC26	SIGNOR-275472
LATS1	phosphorylation down-regulates	WWTR1	SIGNOR-175783
LATS1	phosphorylation down-regulates	WWTR1	SIGNOR-197643