| Name | LATS1 |
| ID | O95835 |
| Role | substrate |
| Enzymatic Domains |
UBA 100-141 PROSITE-ProRule
Protein kinase 705-1010 PROSITE-ProRule
AGC-kinase C-terminal 1011-1090 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NUAK1 | LATS1 | Ser464 | NIPVRSNsFNNPLGN | phosphorylation down-regulates | 19927127 | SIGNOR-161792 |
| PRKACA | LATS1 | – | phosphorylation up-regulates | 23644383 | SIGNOR-236991 | |
| CDK1 | LATS1 | Ser613 | EKKQITTsPITVRKN | phosphorylation up-regulates | 12372621 | SIGNOR-94160 |
| STK3/4 | LATS1 | – | phosphorylation up-regulates | 15688006 | SIGNOR-270217 | |
| STK3 | LATS1 | Ser909 | HQRCLAHsLVGTPNY | phosphorylation up-regulates | 15688006 | SIGNOR-133544 |
| STK4 | LATS1 | Ser909 | HQRCLAHsLVGTPNY | phosphorylation up-regulates | 15688006 | SIGNOR-133551 |
| STK4 | LATS1 | Thr1079 | EHAFYEFtFRRFFDD | phosphorylation up-regulates | 15688006 | SIGNOR-133555 |
| CyclinB/CDK1 | LATS1 | Ser613 | EKKQITTsPITVRKN | phosphorylation up-regulates | 12372621 | SIGNOR-216757 |
| GNA13 | LATS1 | Ser909 | HQRCLAHsLVGTPNY | phosphorylation down-regulates activity | 31569999 | SIGNOR-278051 |
| PPM1F | LATS1 | Thr1079 | EHAFYEFtFRRFFDD | dephosphorylation down-regulates activity | 30863499 | SIGNOR-276989 |
| STK3 | LATS1 | Thr1079 | EHAFYEFtFRRFFDD | phosphorylation up-regulates | 15688006 | SIGNOR-132927 |
| NUAK2 | LATS1 | Ser464 | NIPVRSNsFNNPLGN | phosphorylation down-regulates | 19927127 | SIGNOR-161796 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NUAK1 | phosphorylation up-regulates → | LATS1 PSer464 | phosphorylation down-regulates ⊣ | LATS1 | 19927127 | SIGNOR-161792 |
| CDK1 | phosphorylation up-regulates → | LATS1 PSer613 | phosphorylation up-regulates → | LATS1 | 12372621 | SIGNOR-94160 |
| STK3 | phosphorylation up-regulates → | LATS1 PSer909 | phosphorylation up-regulates → | LATS1 | 15688006 | SIGNOR-133544 |
| STK4 | phosphorylation up-regulates → | LATS1 PSer909 | phosphorylation up-regulates → | LATS1 | 15688006 | SIGNOR-133551 |
| STK4 | phosphorylation up-regulates → | LATS1 PThr1079 | phosphorylation up-regulates → | LATS1 | 15688006 | SIGNOR-133555 |
| CyclinB/CDK1 | phosphorylation up-regulates → | LATS1 PSer613 | phosphorylation up-regulates → | LATS1 | 12372621 | SIGNOR-216757 |
| GNA13 | phosphorylation up-regulates → | LATS1 PSer909 | phosphorylation down-regulates ⊣ | LATS1 | 31569999 | SIGNOR-278051 |
| PPM1F | dephosphorylation down-regulates ⊣ | LATS1 PThr1079 | dephosphorylation up-regulates → | LATS1 | 30863499 | SIGNOR-276989 |
| STK3 | phosphorylation up-regulates → | LATS1 PThr1079 | phosphorylation up-regulates → | LATS1 | 15688006 | SIGNOR-132927 |
| NUAK2 | phosphorylation up-regulates → | LATS1 PSer464 | phosphorylation down-regulates ⊣ | LATS1 | 19927127 | SIGNOR-161796 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NUAK1 | phosphorylation down-regulates | LATS1 | SIGNOR-161792 |
| PRKACA | phosphorylation → up-regulates | LATS1 | SIGNOR-236991 |
| CDK1 | phosphorylation → up-regulates | LATS1 | SIGNOR-94160 |
| STK3/4 | phosphorylation → up-regulates | LATS1 | SIGNOR-270217 |
| STK3 | phosphorylation → up-regulates | LATS1 | SIGNOR-133544 |
| STK4 | phosphorylation → up-regulates | LATS1 | SIGNOR-133551 |
| STK4 | phosphorylation → up-regulates | LATS1 | SIGNOR-133555 |
| CyclinB/CDK1 | phosphorylation → up-regulates | LATS1 | SIGNOR-216757 |
| GNA13 | phosphorylation → down-regulates activity | LATS1 | SIGNOR-278051 |
| PPM1F | dephosphorylation → down-regulates activity | LATS1 | SIGNOR-276989 |
| STK3 | phosphorylation → up-regulates | LATS1 | SIGNOR-132927 |
| NUAK2 | phosphorylation down-regulates | LATS1 | SIGNOR-161796 |