| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1F | LATS1 | Thr1079 | EHAFYEFtFRRFFDD | dephosphorylation down-regulates activity | 30863499 | SIGNOR-276989 |
| STK3 | LATS1 | Thr1079 | EHAFYEFtFRRFFDD | phosphorylation up-regulates | 15688006 | SIGNOR-132927 |
| STK4 | LATS1 | Thr1079 | EHAFYEFtFRRFFDD | phosphorylation up-regulates | 15688006 | SIGNOR-133555 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1F | dephosphorylation down-regulates ⊣ | LATS1 PThr1079 | dephosphorylation up-regulates → | LATS1 | 30863499 | SIGNOR-276989 |
| STK3 | phosphorylation up-regulates → | LATS1 PThr1079 | phosphorylation up-regulates → | LATS1 | 15688006 | SIGNOR-132927 |
| STK4 | phosphorylation up-regulates → | LATS1 PThr1079 | phosphorylation up-regulates → | LATS1 | 15688006 | SIGNOR-133555 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1F | dephosphorylation → down-regulates activity | LATS1 | SIGNOR-276989 |
| STK3 | phosphorylation → up-regulates | LATS1 | SIGNOR-132927 |
| STK4 | phosphorylation → up-regulates | LATS1 | SIGNOR-133555 |
